Microglia are implicated in all stages of multiple sclerosis (MS). Microglia alterations are
detected by positron emission tomography in people living with MS prior to the formation of …

Microglia are the resident innate immune cells in the brain with a major role in orchestrating
immune responses. They also provide a frontline of host defense in the central nervous …

Hematopoietic stem cell transplantation (HSCT) can replace endogenous microglia with
circulation-derived macrophages but has high mortality. To mitigate the risks of HSCT and …

Background Schizophrenia is a complex psychiatric disorder that includes positive and
negative symptoms but also debilitating cognitive deficits. Current pharmacological …

Chronic inflammation contributes to the onset and progression of cardiovascular disease
and other degenerative diseases of aging. But does it have to? This article considers the …

Occupational injuries and toxicant exposures lead to the development of neuroinflammation
by activating distinct mechanistic signaling cascades that ultimately culminate in the …

A critical step in preserving protein homeostasis is the recognition, binding, unfolding, and
translocation of protein substrates by six AAA-ATPase proteasome subunits (ATPase …

Various age-related diseases involve systemic inflammation, ie a stereotyped series of acute
immune system responses, and aging itself is commonly associated with low-grade …

Alzheimer's disease (AD) is the most common form of neurodegenerative disease and is
considered the main cause of dementia worldwide. Genome-wide association studies …

Obesity is a multifactorial disease that continues to increase in prevalence worldwide.
Emerging evidence has shown that the development of obesity may be influenced by …