Pathophysiology and epidemiology of abdominal aortic aneurysms

IM Nordon, RJ Hinchliffe, IM Loftus… - Nature reviews …, 2011 - nature.com
Abdominal aortic aneurysms (AAAs) are found in up to 8% of men aged> 65 years, yet
usually remain asymptomatic until they rupture. Rupture of an AAA and its associated …

Extracellular matrix molecules: potential targets in pharmacotherapy

H Järveläinen, A Sainio, M Koulu, TN Wight… - Pharmacological …, 2009 - ASPET
The extracellular matrix (ECM) consists of numerous macromolecules classified traditionally
into collagens, elastin, and microfibrillar proteins, proteoglycans including hyaluronan, and …

AAA revisited: a comprehensive review of risk factors, management, and hallmarks of pathogenesis

V Kessler, J Klopf, W Eilenberg, C Neumayer… - Biomedicines, 2022 - mdpi.com
Despite declining incidence and mortality rates in many countries, the abdominal aortic
aneurysm (AAA) continues to represent a life-threatening cardiovascular condition with an …

Abdominal aortic aneurysm—an independent disease to atherosclerosis?

BJ Toghill, A Saratzis, MJ Bown - Cardiovascular Pathology, 2017 - Elsevier
Atherosclerosis and abdominal aortic aneurysms (AAAs) are multifactorial and polygenic
diseases with known environmental and genetic risk factors that contribute toward disease …

Atherosclerosis in abdominal aortic aneurysms: a causal event or a process running in parallel? The Tromsø study

SH Johnsen, SH Forsdahl, K Singh… - … , and vascular biology, 2010 - Am Heart Assoc
Objective—The pathogenesis of abdominal aortic aneurysm (AAA) formation is poorly
understood. We investigated the relationship between carotid, femoral, and coronary …

The role of endothelial dysfunction in aortic aneurysms

G Siasos, K Mourouzis, E Oikonomou… - Current …, 2015 - ingentaconnect.com
Abdominal aortic aneurysm is a vascular disease which, despite the fact that it shares
common risk factors with atherosclerosis, develops in parallel but as a partly independent …

Review of current theories for abdominal aortic aneurysm pathogenesis

IM Nordon, RJ Hinchliffe, PJ Holt, IM Loftus… - …, 2009 - journals.sagepub.com
Atherosclerotic plaques are a feature of abdominal aortic aneurysms (AAAs).
Atherosclerosis and AAA appear to share similar risk factors. These observations have led to …

Simvastatin attenuates abdominal aortic aneurysm formation favoured by lack of Nrf2 transcriptional activity

A Kopacz, E Werner… - Oxidative Medicine …, 2020 - Wiley Online Library
Surgical intervention is currently the only option for an abdominal aortic aneurysm (AAA),
preventing its rupture and sudden death of a patient. Therefore, it is crucial to determine the …

Circular RNA expression: Its potential regulation and function in abdominal aortic aneurysms

Y Han, H Zhang, C Bian, C Chen, S Tu… - Oxidative medicine …, 2021 - Wiley Online Library
Abdominal aortic aneurysms (AAAs) have posed a great threat to human life, and the
necessity of its monitoring and treatment is decided by symptomatology and/or the aneurysm …

The association of obesity with abdominal aortic aneurysm presence and growth

O Cronin, PJ Walker, J Golledge - Atherosclerosis, 2013 - Elsevier
OBJECTIVES: The importance of obesity as a risk factor for atherothrombosis has been
clearly demonstrated. Abdominal aortic aneurysm (AAA) is believed to develop due to …