Neuronal Hippo signaling: From development to diseases

MR Sahu, AC Mondal - Developmental neurobiology, 2021 - Wiley Online Library
Hippo signaling pathway is a highly conserved and familiar tissue growth regulator, primarily
dealing with cell survival, cell proliferation, and apoptosis. The Yes‐associated protein …

Overview of neural tube defects: gene–environment interactions, preventative approaches and future perspectives

J Isaković, I Šimunić, D Jagečić, V Hribljan, D Mitrečić - Biomedicines, 2022 - mdpi.com
Neural tube defects (NTDs) are the second most common congenital malformations of
humans, characterized by impaired development of the central nervous system. Even …

Yap and Taz promote osteogenesis and prevent chondrogenesis in neural crest cells in vitro and in vivo

X Zhao, L Tang, TP Le, BH Nguyen, W Chen… - Science …, 2022 - science.org
Neural crest cells (NCCs) are multipotent stem cells that can differentiate into multiple cell
types, including the osteoblasts and chondrocytes, and constitute most of the craniofacial …

GPR65 promotes intestinal mucosal Th1 and Th17 cell differentiation and gut inflammation through downregulating NUAK2

R Lin, W Wu, H Chen, H Gao, X Wu, G Li… - Clinical and …, 2022 - Wiley Online Library
G protein‐coupled receptor 65 (GPR65), a susceptibility gene for inflammatory bowel
diseases (IBD), has been identified to promote Th17 cell pathogenicity and induce T cell …

A Shared Pathogenic Mechanism for Valproic Acid and SHROOM3 Knockout in a Brain Organoid Model of Neural Tube Defects

TN Takla, J Luo, R Sudyk, J Huang, JC Walker… - Cells, 2023 - mdpi.com
Neural tube defects (NTDs), including anencephaly and spina bifida, are common major
malformations of fetal development resulting from incomplete closure of the neural tube …

Noncanonical function of folate through folate receptor 1 during neural tube formation

OA Balashova, AA Panoutsopoulos, O Visina… - Nature …, 2024 - nature.com
Folate supplementation reduces the occurrence of neural tube defects (NTDs), birth defects
consisting in the failure of the neural tube to form and close. The mechanisms underlying …

NUAK2 and RCan2 participate in the p53 mutant pro-tumorigenic network

E Mammarella, C Zampieri, E Panatta, G Melino… - Biology Direct, 2021 - Springer
Most inactivating mutations in TP53 gene generates neomorphic forms of p53 proteins that
experimental evidence and clinical observations suggest to exert gain-of-function effects …

LATS1/2 control TGFB-directed epithelial-to-mesenchymal transition in the murine dorsal cranial neuroepithelium through YAP regulation

IM Martínez Traverso, JD Steimle, X Zhao… - …, 2022 - journals.biologists.com
Hippo signaling, an evolutionarily conserved kinase cascade involved in organ size control,
plays key roles in various tissue developmental processes, but its role in craniofacial …

Depletion of NUAK2 blocks the stemness and angiogenesis and facilitates senescence of lung adenocarcinoma cells via enhancing ferroptosis

J Fan, L Xue, H Lin, J Luo - Cell Division, 2024 - Springer
NUAK family kinase 2 (NUAK2) has been identified as an important mediator for tumor
progression in multiple malignancies. Nevertheless, its role in lung adenocarcinoma (LUAD) …

NUAK1 And NUAK2 fine-tune TGF-β signaling

RAJ van de Vis, A Moustakas, LP van der Heide - Cancers, 2021 - mdpi.com
Simple Summary TGF-β is a growth factor implicated in a plethora of processes and
malignancies, which include cancer and fibrosis. Via binding to its receptor, TGF-β activates …