Neuronal Hippo signaling: From development to diseases
Hippo signaling pathway is a highly conserved and familiar tissue growth regulator, primarily
dealing with cell survival, cell proliferation, and apoptosis. The Yes‐associated protein …
dealing with cell survival, cell proliferation, and apoptosis. The Yes‐associated protein …
Overview of neural tube defects: gene–environment interactions, preventative approaches and future perspectives
Neural tube defects (NTDs) are the second most common congenital malformations of
humans, characterized by impaired development of the central nervous system. Even …
humans, characterized by impaired development of the central nervous system. Even …
Yap and Taz promote osteogenesis and prevent chondrogenesis in neural crest cells in vitro and in vivo
Neural crest cells (NCCs) are multipotent stem cells that can differentiate into multiple cell
types, including the osteoblasts and chondrocytes, and constitute most of the craniofacial …
types, including the osteoblasts and chondrocytes, and constitute most of the craniofacial …
GPR65 promotes intestinal mucosal Th1 and Th17 cell differentiation and gut inflammation through downregulating NUAK2
R Lin, W Wu, H Chen, H Gao, X Wu, G Li… - Clinical and …, 2022 - Wiley Online Library
G protein‐coupled receptor 65 (GPR65), a susceptibility gene for inflammatory bowel
diseases (IBD), has been identified to promote Th17 cell pathogenicity and induce T cell …
diseases (IBD), has been identified to promote Th17 cell pathogenicity and induce T cell …
A Shared Pathogenic Mechanism for Valproic Acid and SHROOM3 Knockout in a Brain Organoid Model of Neural Tube Defects
TN Takla, J Luo, R Sudyk, J Huang, JC Walker… - Cells, 2023 - mdpi.com
Neural tube defects (NTDs), including anencephaly and spina bifida, are common major
malformations of fetal development resulting from incomplete closure of the neural tube …
malformations of fetal development resulting from incomplete closure of the neural tube …
Noncanonical function of folate through folate receptor 1 during neural tube formation
OA Balashova, AA Panoutsopoulos, O Visina… - Nature …, 2024 - nature.com
Folate supplementation reduces the occurrence of neural tube defects (NTDs), birth defects
consisting in the failure of the neural tube to form and close. The mechanisms underlying …
consisting in the failure of the neural tube to form and close. The mechanisms underlying …
NUAK2 and RCan2 participate in the p53 mutant pro-tumorigenic network
E Mammarella, C Zampieri, E Panatta, G Melino… - Biology Direct, 2021 - Springer
Most inactivating mutations in TP53 gene generates neomorphic forms of p53 proteins that
experimental evidence and clinical observations suggest to exert gain-of-function effects …
experimental evidence and clinical observations suggest to exert gain-of-function effects …
LATS1/2 control TGFB-directed epithelial-to-mesenchymal transition in the murine dorsal cranial neuroepithelium through YAP regulation
IM Martínez Traverso, JD Steimle, X Zhao… - …, 2022 - journals.biologists.com
Hippo signaling, an evolutionarily conserved kinase cascade involved in organ size control,
plays key roles in various tissue developmental processes, but its role in craniofacial …
plays key roles in various tissue developmental processes, but its role in craniofacial …
Depletion of NUAK2 blocks the stemness and angiogenesis and facilitates senescence of lung adenocarcinoma cells via enhancing ferroptosis
J Fan, L Xue, H Lin, J Luo - Cell Division, 2024 - Springer
NUAK family kinase 2 (NUAK2) has been identified as an important mediator for tumor
progression in multiple malignancies. Nevertheless, its role in lung adenocarcinoma (LUAD) …
progression in multiple malignancies. Nevertheless, its role in lung adenocarcinoma (LUAD) …
NUAK1 And NUAK2 fine-tune TGF-β signaling
RAJ van de Vis, A Moustakas, LP van der Heide - Cancers, 2021 - mdpi.com
Simple Summary TGF-β is a growth factor implicated in a plethora of processes and
malignancies, which include cancer and fibrosis. Via binding to its receptor, TGF-β activates …
malignancies, which include cancer and fibrosis. Via binding to its receptor, TGF-β activates …