The mammalian brain depends upon glucose as its main source of energy, and tight
regulation of glucose metabolism is critical for brain physiology. Consistent with its critical …

Scientific evidence supports the notion that migraine pathophysiology involves inherited
alteration of brain excitability, intracranial arterial dilatation, recurrent activation, and …

Background Migraine is a complex neurovascular disorder with a strong genetic component.
There are rare monogenic forms of migraine, as well as more common polygenic forms; …

Punctuated episodes of spreading depolarizations erupt in the brain, encumbering tissue
structure and function, and raising fascinating unanswered questions concerning their …

Aim To provide an overview of mechanisms underlying craniofacial pain; to highlight
peripheral and central adaptations that may promote chronification of pain in craniofacial …

Introduction Migraine prophylactic therapy has changed over recent years with the
development and approval of monoclonal antibodies (mAbs) targeting the calcitonin gene …

Migraine is a complex, debilitating neurovascular disorder, typically characterized by
recurring, incapacitating attacks of severe headache often accompanied by nausea and …

Hemiplegic migraine (HM) is a clinically and genetically heterogeneous condition with
attacks of headache and motor weakness which may be associated with impaired …

Migraine is a common disabling brain disorder. A subtype of migraine with aura (familial
hemiplegic migraine type 2: FHM 2) is caused by loss‐of‐function mutations in α2 Na+, K+ …

The aims of this study were to 1) compare resting state functional connectivity (rs-fc) of the
periaqueductal gray (PAG), a key region in the descending pain modulatory system (DPMS) …