Role of O-linked N-acetylglucosamine protein modification in cellular (patho)physiology
In the mid-1980s, the identification of serine and threonine residues on nuclear and
cytoplasmic proteins modified by a N-acetylglucosamine moiety (O-GlcNAc) via an O …
cytoplasmic proteins modified by a N-acetylglucosamine moiety (O-GlcNAc) via an O …
Analytical and biochemical perspectives of protein O-GlcNAcylation
Protein O-linked β-N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) is a
unique monosaccharide modification discovered in the early 1980s. With the technological …
unique monosaccharide modification discovered in the early 1980s. With the technological …
A little sugar goes a long way: the cell biology of O-GlcNAc
MR Bond, JA Hanover - Journal of Cell Biology, 2015 - rupress.org
Unlike the complex glycans decorating the cell surface, the O-linked β-N-acetyl glucosamine
(O-GlcNAc) modification is a simple intracellular Ser/Thr-linked monosaccharide that is …
(O-GlcNAc) modification is a simple intracellular Ser/Thr-linked monosaccharide that is …
The folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation
M Shang, H Yang, R Yang, T Chen, Y Fu, Y Li… - Nature …, 2021 - nature.com
Metabolic enzymes and metabolites display non-metabolic functions in immune cell
signalling that modulate immune attack ability. However, whether and how a tumour's …
signalling that modulate immune attack ability. However, whether and how a tumour's …
O-GlcNAc as an integrator of signaling pathways
O-GlcNAcylation is an important posttranslational modification governed by a single pair of
enzymes–O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). These two enzymes …
enzymes–O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). These two enzymes …
Remembering winter through vernalisation
S Xu, K Chong - Nature Plants, 2018 - nature.com
Vernalisation is the programmed physiological process in which prolonged cold-exposure
provides competency to flower in plants; widely found in winter and biennial species, such …
provides competency to flower in plants; widely found in winter and biennial species, such …
Protein O-GlcNAcylation and the regulation of energy homeostasis: lessons from knock-out mouse models
T Issad, H Al-Mukh, A Bouaboud, P Pagesy - Journal of Biomedical …, 2022 - Springer
O-GlcNAcylation corresponds to the addition of N-Acetylglucosamine (GlcNAc) on serine or
threonine residues of cytosolic, nuclear and mitochondrial proteins. This reversible …
threonine residues of cytosolic, nuclear and mitochondrial proteins. This reversible …
Identification and characterization of a missense mutation in the O-linked β-N-acetylglucosamine (O-GlcNAc) transferase gene that segregates with X-linked …
O-GlcNAc is a regulatory post-translational modification of nucleocytoplasmic proteins that
has been implicated in multiple biological processes, including transcription. In humans …
has been implicated in multiple biological processes, including transcription. In humans …
O-GlcNAcylation of fumarase maintains tumour growth under glucose deficiency
T Wang, Q Yu, J Li, B Hu, Q Zhao, C Ma, W Huang… - Nature cell …, 2017 - nature.com
Chromatin-associated fumarase (FH) affects histone methylation via its metabolic activity.
However, whether this effect is involved in gene transcription remains to be clarified. In this …
However, whether this effect is involved in gene transcription remains to be clarified. In this …
O-GlcNAcylation: A regulator of tau pathology and neurodegeneration
O-GlcNAcylation is the posttranslational modification of intracellular proteins by O-linked β-N-
acetylglucosamine (O-GlcNAc). The discovery of O-GlcNAc modification of tau and its impact …
acetylglucosamine (O-GlcNAc). The discovery of O-GlcNAc modification of tau and its impact …