The first major developmental transition in vertebrate embryos is the maternal-to-zygotic
transition (MZT) when maternal mRNAs are degraded and zygotic transcription begins …

Polyploidy is a key mechanism of genome evolution and speciation, particularly in plants.
Many aspects of polyploidy have been elucidated with the tools that have become available …

Size and shape are important aspects of nuclear structure. While normal cells maintain
nuclear size within a defined range, altered nuclear size and shape are associated with a …

Ploidy and size phenomena are observed to be correlated across several biological scales,
from subcellular to organismal. Two kinds of ploidy change can affect plants. Whole-genome …

Early embryogenesis is accompanied by reductive cell divisions requiring that subcellular
structures adapt to a range of cell sizes. The interphase nucleus and mitotic spindle scale …

Abstract The human Immunodeficiency Centromeric Instability Facial Anomalies (ICF) 4
syndrome is a severe disease with increased mortality caused by mutation in the LSH gene …

Cell size, cell growth, and cell cycle events are necessarily intertwined to achieve robust
bacterial replication. Yet, a comprehensive and integrated view of these fundamental …

How intracellular organelles acquire their characteristic sizes is a fundamental question in
cell biology. Given stereotypical changes in nuclear size in cancer, it is important to …

During differentiation and development, cell fate and identity are established by waves of
genetic reprogramming. Although the mechanisms are largely unknown, during these …

Nuclear size plays pivotal roles in gene expression, embryo development, and disease. A
central hypothesis in organisms ranging from yeast to vertebrates is that nuclear size scales …