Zygotic genome activation in vertebrates
The first major developmental transition in vertebrate embryos is the maternal-to-zygotic
transition (MZT) when maternal mRNAs are degraded and zygotic transcription begins …
transition (MZT) when maternal mRNAs are degraded and zygotic transcription begins …
Polyploidy, the nucleotype, and novelty: the impact of genome doubling on the biology of the cell
Polyploidy is a key mechanism of genome evolution and speciation, particularly in plants.
Many aspects of polyploidy have been elucidated with the tools that have become available …
Many aspects of polyploidy have been elucidated with the tools that have become available …
Recent advances in understanding nuclear size and shape
Size and shape are important aspects of nuclear structure. While normal cells maintain
nuclear size within a defined range, altered nuclear size and shape are associated with a …
nuclear size within a defined range, altered nuclear size and shape are associated with a …
Ploidy and size at multiple scales in the Arabidopsis sepal
Ploidy and size phenomena are observed to be correlated across several biological scales,
from subcellular to organismal. Two kinds of ploidy change can affect plants. Whole-genome …
from subcellular to organismal. Two kinds of ploidy change can affect plants. Whole-genome …
Importin α partitioning to the plasma membrane regulates intracellular scaling
C Brownlee, R Heald - Cell, 2019 - cell.com
Early embryogenesis is accompanied by reductive cell divisions requiring that subcellular
structures adapt to a range of cell sizes. The interphase nucleus and mitotic spindle scale …
structures adapt to a range of cell sizes. The interphase nucleus and mitotic spindle scale …
LSH mediates gene repression through macroH2A deposition
Abstract The human Immunodeficiency Centromeric Instability Facial Anomalies (ICF) 4
syndrome is a severe disease with increased mortality caused by mutation in the LSH gene …
syndrome is a severe disease with increased mortality caused by mutation in the LSH gene …
Genomewide phenotypic analysis of growth, cell morphogenesis, and cell cycle events in Escherichia coli
Cell size, cell growth, and cell cycle events are necessarily intertwined to achieve robust
bacterial replication. Yet, a comprehensive and integrated view of these fundamental …
bacterial replication. Yet, a comprehensive and integrated view of these fundamental …
The nucleoporin ELYS regulates nuclear size by controlling NPC number and nuclear import capacity
How intracellular organelles acquire their characteristic sizes is a fundamental question in
cell biology. Given stereotypical changes in nuclear size in cancer, it is important to …
cell biology. Given stereotypical changes in nuclear size in cancer, it is important to …
β‐Actin‐dependent global chromatin organization and gene expression programs control cellular identity
X Xie, B Almuzzaini, N Drou, S Kremb… - The FASEB …, 2018 - Wiley Online Library
During differentiation and development, cell fate and identity are established by waves of
genetic reprogramming. Although the mechanisms are largely unknown, during these …
genetic reprogramming. Although the mechanisms are largely unknown, during these …
The perinuclear ER scales nuclear size independently of cell size in early embryos
Nuclear size plays pivotal roles in gene expression, embryo development, and disease. A
central hypothesis in organisms ranging from yeast to vertebrates is that nuclear size scales …
central hypothesis in organisms ranging from yeast to vertebrates is that nuclear size scales …