Ever since the discovery of DNA methylation at cytosine residues, the role of this so called
fifth base has been extensively studied and debated. Until recently, the majority of DNA …

Over the course of an individual's lifetime, normal human cells accumulate mutations. Here
we compare the mutational landscape in 29 cell types from the soma and germline using …

Abstract Changes in gene expression that reset a cell program from a normal to a diseased
state involve multiple genetic circuitries, creating a characteristic signature of gene …

DNA replication timing is known to facilitate the establishment of the epigenome, however,
the intimate connection between replication timing and changes to the genome and …

DNA methylation is a critical epigenetic mark in mammalian cells. Many aspects of DNA
methylation maintenance have been characterized; however, the exact kinetics of post …

Szyf M. The early‐life social environment and DNA methylation. DNA methylation is a
chemical modification of DNA that confers, upon identical sequences, different identities that …

DNA methylation is an epigenetic mark associated with regulation of transcription and
genome structure. These markers have been investigated in a variety of cancer settings for …

Genome stability requires tight regulation of DNA replication to ensure that the entire
genome of the cell is duplicated once and only once per cell cycle. In mammalian cells …

Background Nuclear alterations are a well-known manifestation of cancer. However, little is
known about the early, microscopically-undetectable stages of malignant transformation …

Purpose: Even though recent studies have shown that genetic changes at enhancers can
influence carcinogenesis, most methylomic studies have focused on changes at promoters …