[HTML][HTML] The secretion profile of mesenchymal stem cells and potential applications in treating human diseases

Y Han, J Yang, J Fang, Y Zhou, E Candi… - … and Targeted Therapy, 2022 - nature.com
Mesenchymal stromal/stem cells (MSCs) possess multi-lineage differentiation and self-
renewal potentials. MSCs-based therapies have been widely utilized for the treatment of …

[HTML][HTML] Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool?

M Kou, L Huang, J Yang, Z Chiang, S Chen, J Liu… - Cell death & …, 2022 - nature.com
Mesenchymal stem cells (MSCs) can be widely isolated from various tissues including bone
marrow, umbilical cord, and adipose tissue, with the potential for self-renewal and …

[HTML][HTML] A paradigm shift in cell-free approach: the emerging role of MSCs-derived exosomes in regenerative medicine

S Moghadasi, M Elveny, HS Rahman… - Journal of translational …, 2021 - Springer
Recently, mesenchymal stem/stromal cells (MSCs) due to their pro-angiogenic, anti-
apoptotic, and immunoregulatory competencies along with fewer ethical issues are …

Macrophage polarization and diabetic wound healing

AE Louiselle, SM Niemiec, C Zgheib, KW Liechty - Translational Research, 2021 - Elsevier
Diabetes mellitus is a costly disease and nearly one-third of these costs are attributed to
management of diabetic foot disease including chronic, non-healing, diabetic foot ulcers …

Anti-inflammatory and M2 macrophage polarization-promoting effect of mesenchymal stem cell-derived exosomes

M Arabpour, A Saghazadeh, N Rezaei - International …, 2021 - Elsevier
Mesenchymal stem cells (MSCs) are multipotent cells beneficial in regenerative medicine
and tissue repair. The therapeutic potential of MSCs for inflammatory diseases and …

[HTML][HTML] Exosomes derived from pioglitazone-pretreated MSCs accelerate diabetic wound healing through enhancing angiogenesis

Y Hu, R Tao, L Chen, Y Xiong, H Xue, L Hu… - Journal of …, 2021 - Springer
Background Enhanced angiogenesis can promote diabetic wound healing. Mesenchymal
stem cells (MSCs)-derived exosomes, which are cell-free therapeutics, are promising …

[HTML][HTML] Hypoxia adipose stem cell-derived exosomes promote high-quality healing of diabetic wound involves activation of PI3K/Akt pathways

J Wang, H Wu, Y Peng, Y Zhao, Y Qin, Y Zhang… - Journal of …, 2021 - Springer
Refractory diabetic wounds can cause persistent inflammation and delayed healing due to
hypoxia. Currently, no optimal solution is available. Exosomes of adipose stem cells (ADSCs …

[HTML][HTML] Differential therapeutic effect of extracellular vesicles derived by bone marrow and adipose mesenchymal stem cells on wound healing of diabetic ulcers and …

M Pomatto, C Gai, F Negro, M Cedrino… - International journal of …, 2021 - mdpi.com
Extracellular vesicles (EVs) derived from mesenchymal stem cells isolated from both bone
marrow (BMSCs) and adipose tissue (ADSCs) show potential therapeutic effects. These …

Extracellular vesicles derived from melatonin‐preconditioned mesenchymal stem cells containing USP29 repair traumatic spinal cord injury by stabilizing NRF2

W Liu, P Tang, J Wang, W Ye, X Ge… - Journal of Pineal …, 2021 - Wiley Online Library
Spinal cord injury (SCI) is a devastating trauma that leads to irreversible motor and sensory
dysfunction and is, so far, without effective treatment. Recently, however, nano‐sized …

Preconditioning and Engineering Strategies for Improving the Efficacy of Mesenchymal Stem Cell‐Derived Exosomes in Cell‐Free Therapy

S Chen, F Sun, H Qian, W Xu, J Jiang - Stem cells international, 2022 - Wiley Online Library
Mesenchymal stem cells (MSCs) have been widely applied to regenerative medicine owing
to their multiple differentiation, self‐renewal, and immunomodulatory abilities. Exosomes are …