How ERAP1 and ERAP2 shape the peptidomes of disease-associated MHC-I proteins
JA López de Castro - Frontiers in Immunology, 2018 - frontiersin.org
Four inflammatory diseases are strongly associated with Major Histocompatibility Complex
class I (MHC-I) molecules: birdshot chorioretinopathy (HLA-A* 29: 02), ankylosing …
class I (MHC-I) molecules: birdshot chorioretinopathy (HLA-A* 29: 02), ankylosing …
Multiple causal variants underlie genetic associations in humans
Associations between genetic variation and traits are often in noncoding regions with strong
linkage disequilibrium (LD), where a single causal variant is assumed to underlie the …
linkage disequilibrium (LD), where a single causal variant is assumed to underlie the …
Regulation of ERAP1 and ERAP2 genes and their disfunction in human cancer
The endoplasmic reticulum (ER) aminopeptidases ERAP1 and ERAP2 are two
multifunctional enzymes playing an important role in the biological processes requiring …
multifunctional enzymes playing an important role in the biological processes requiring …
The roles of ERAP1 and ERAP2 in autoimmunity and cancer immunity: New insights and perspective
F Babaie, R Hosseinzadeh, M Ebrazeh… - Molecular …, 2020 - Elsevier
Autoimmunity and cancer affect millions worldwide and both, in principal, result from
dysregulated immune responses. There are many well-known molecules involved in …
dysregulated immune responses. There are many well-known molecules involved in …
The multifaceted nature of aminopeptidases ERAP1, ERAP2, and LNPEP: from evolution to disease
F Paladini, MT Fiorillo, V Tedeschi, B Mattorre… - Frontiers in …, 2020 - frontiersin.org
In the human genome, the aminopeptidases ERAP1, ERAP2 and LNPEP lie contiguously on
chromosome 5. They share sequence homology, functions and associations with immune …
chromosome 5. They share sequence homology, functions and associations with immune …
An overview on ERAP roles in infectious diseases
Endoplasmic reticulum (ER) aminopeptidases ERAP1 and ERAP2 (ERAPs) are crucial
enzymes shaping the major histocompatibility complex I (MHC I) immunopeptidome. In the …
enzymes shaping the major histocompatibility complex I (MHC I) immunopeptidome. In the …
Influence of ERAP1 and ERAP2 gene polymorphisms on disease susceptibility in different populations
Y Yao, N Liu, Z Zhou, L Shi - Human immunology, 2019 - Elsevier
The endoplasmic reticulum aminopeptidases (ERAPs), ERAP1 and ERAP2, makes a role in
shaping the HLA class I peptidome by trimming peptides to the optimal size in MHC-class I …
shaping the HLA class I peptidome by trimming peptides to the optimal size in MHC-class I …
[HTML][HTML] ERAP, KIR, and HLA-C profile in recurrent implantation failure
K Piekarska, P Radwan, A Tarnowska… - Frontiers in …, 2021 - frontiersin.org
The mother's uterine immune system is dominated by uterine natural killer (NK) cells during
the first trimester of pregnancy. These cells express killer cell immunoglobulin-like receptors …
the first trimester of pregnancy. These cells express killer cell immunoglobulin-like receptors …
The impact of the 'mis-peptidome'on HLA class I-mediated diseases: contribution of ERAP1 and ERAP2 and effects on the immune response
V Tedeschi, G Paldino, F Paladini, B Mattorre… - International Journal of …, 2020 - mdpi.com
The strong association with the Major Histocompatibility Complex (MHC) class I genes
represents a shared trait for a group of autoimmune/autoinflammatory disorders having in …
represents a shared trait for a group of autoimmune/autoinflammatory disorders having in …
Intracellular antigen processing by ERAP2: Molecular mechanism and roles in health and disease
JAL de Castro, E Stratikos - Human Immunology, 2019 - Elsevier
Abstract Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) is an intracellular enzyme
localized in the ER that has been shown to play roles in the generation of peptides that …
localized in the ER that has been shown to play roles in the generation of peptides that …