Background Sepsis and septic shock remain drivers for mortality in critically ill patients. The
heterogeneity of the syndrome hinders the generation of reproducible numbers on mortality …

Sepsis remains a major cause of morbidity and mortality in both low-and high-income
countries. Antibiotic therapy and supportive care have significantly improved survival …

Sepsis is characterized by a dysregulated immune response to infections that causes life-
threatening organ dysfunction and even death. When infections occur, bacterial cell wall …

Numerous studies suggest that the incidence of sepsis has been steadily increasing over
the past several decades while mortality rates are falling. However, reliably assessing trends …

Sepsis is characterised by a dysregulated host immune response to infection. Despite
recognition of its significance, immune status monitoring is not implemented in clinical …

Background Fluid therapy is a cornerstone in the treatment of sepsis. Recently, the
guidelines have recommended the combined administration that using crystalloids plus …

OBJECTIVES: Sepsis is a common condition in the ICU. Despite much research, its
prognosis remains poor. In 2017, a retrospective before/after study reported promising …

OBJECTIVES: Beta-lactam antibiotics exhibit high interindividual variability in drug
concentrations in patients with critical illness which led to an interest in the use of …

The “normal” immune response to an insult triggers a highly regulated response determined
by the interaction of various immunocompetent cells with pro-and anti-inflammatory …

Sepsis is a life-threatening condition caused by an exaggerated reaction of the body to an
infection, that leads to organ failure or even death. Since sepsis can kill a patient even in just …