Synaptic plasticity is a key component of the learning machinery in the brain. It is vital that
such plasticity be tightly regulated so that it occurs to the proper extent at the proper time …

Activity-dependent changes in the strength of excitatory synapses are a cellular mechanism
for the plasticity of neuronal networks that is widely recognized to underlie cognitive …

Alterations of the dopaminergic (DAergic) system are frequently reported in Alzheimer's
disease (AD) patients and are commonly linked to cognitive and non-cognitive symptoms …

Memory formation is typically divided into phases associated with encoding, storage,
consolidation, and retrieval. The neural determinants of these phases are thought to differ …

The repeated use of drugs that directly or indirectly stimulate dopamine transmission carry
addiction liability and produce enduring pathological changes in the brain circuitry that …

The past two decades have witnessed a dramatic accumulation of evidence indicating that
the excitatory amino acid glutamate plays an important role in drug addiction and …

Research on dopamine lies at the intersection of sophisticated theoretical and
neurobiological approaches to learning and memory. Dopamine has been shown to be …

This review focuses on cocaine-induced postsynaptic plasticity in the nucleus accumbens
(NAc) involving changes in AMPA receptor (AMPAR) transmission. First, fundamental …

The dynamic expression of AMPA-type glutamate receptors (AMPA-R) at synapses is a key
determinant of synaptic plasticity, including neuroadaptations to drugs of abuse. Recently …

α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors mediate the
majority of excitatory synaptic transmission in the brain. Recent studies have shown that …