In the past 15 years, B cells have been rediscovered to be not merely bystanders but rather
active participants in autoimmune aetiology. This has been fuelled in part by the clinical …

Current therapies for multiple sclerosis (MS) reduce both relapses and relapse-associated
worsening of disability, which is assumed to be mainly associated with transient infiltration of …

Background and Objectives People with multiple sclerosis (MS) are a vulnerable group for
severe coronavirus disease 2019 (COVID-19), particularly those taking immunosuppressive …

In the last decades, evidence suggesting the direct or indirect involvement of B cells on
multiple sclerosis (MS) pathogenesis has accumulated. The increased amount of data on …

These updated EBMT guidelines review the clinical evidence, registry activity and
mechanisms of action of haematopoietic stem cell transplantation (HSCT) in multiple …

Purpose of review This review presents a comprehensive analysis of the current high-
efficacy disease-modifying therapies (DMTs) available for treatment of multiple sclerosis …

The immune system plays a significant role in multiple sclerosis. While MS was historically
thought to be T cell-mediated, multiple pieces of evidence now support the view that B cells …

Multiple sclerosis (MS) is a chronic progressive demyelinating disease of the central
nervous system (CNS) due to an increase of abnormal peripherally auto-reactive T …

Microglia, the resident myeloid cells in the central nervous system (CNS) play critical roles in
shaping the brain during development, responding to invading pathogens, and clearing …

Objective To evaluate the safety of rituximab treatment before and during pregnancy in
women with MS and neuromyelitis optica spectrum disorders (NMOSDs) who may be at risk …