Colorectal cancer (CRC) shows variable underlying molecular changes with two major
mechanisms of genetic instability: chromosomal instability and microsatellite instability. This …

Colorectal cancer (CRC) is a leading cause of cancer death worldwide. It includes different
subtypes that differ in their clinical and prognostic features. In the past decade, in addition to …

Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. It results from an
accumulation of genetic and epigenetic changes in colon epithelial cells, which transforms …

Due to differences in anatomy, primary rectal and colon cancer require different staging
procedures, different neo-adjuvant treatment and different surgical approaches. For …

Lynch syndrome (LS) is characterised by predisposition to colorectal, endometrial, and other
cancers and is caused by inherited pathogenic variants affecting the DNA mismatch repair …

Colorectal cancer (CRC) is the second most common newly diagnosed cancer and accounts
for the second highest number of cancer related deaths in Australia, the third worldwide and …

Colorectal cancer is one of the most frequent solid tumors in the Western world. Treatment
options are dependent on the stage of the disease, the performance status of the patient …

High dietary fat causes increased bile acid secretion into the gastrointestinal tract and is
associated with colon cancer. Since the bile acid deoxycholic acid (DOC) is suggested to be …

Introduction Advances in our understanding of the molecular genetics and epigenetics of
colorectal cancer have led to novel insights into the pathogenesis of this common cancer …

Colorectal cancer (CRC) develops through a multistage process that results from the
progressive accumulation of genetic mutations, and frequently as a result of mutations in the …