DNA methylation is one of the most intensely studied epigenetic modifications in mammals.
In normal cells, it assures the proper regulation of gene expression and stable gene …

Cancer is the second leading cause of death in US. Despite the emergence of new, targeted
agents, and the use of various therapeutic combinations, none of the available treatment …

Epigenetic mechanisms, which include DNA methylation, a variety of post-translational
modifications of histone proteins (acetylation, phosphorylation, methylation, ubiquitination …

The timing of puberty is controlled by many genes. The elements coordinating this process
have not, however, been identified. Here we show that an epigenetic mechanism of …

MicroRNAs (miR) are a class of small (∼ 21 nucleotide) noncoding RNAs that, in general,
negatively regulate gene expression. Some miRs harboring CGIs undergo methylation …

Poly (ADP-ribose) polymerase inhibitors (PARPis) are clinically effective predominantly for
BRCA-mutant tumors. We introduce a mechanism-based strategy to enhance PARPi efficacy …

Reactivation of silenced tumor suppressor genes by 5-azacytidine (Vidaza) and its congener
5-aza-2′-deoxycytidine (decitabine) has provided an alternate approach to cancer therapy …

Life expectancy has grown dramatically in modern times. This increase, however, is not
accompanied by the same increase in healthspan. Efforts to extend healthspan through …

While only a small part of the human genome encodes for proteins, biological functions for
the so-called junk genome are increasingly being recognized through high-throughput …

Carcinogenesis is a complex and multistep process that involves the accumulation of
successive transformational events driven by genetic mutations and epigenetic alterations …