Importance Approximately 18.6 million people worldwide are affected by a diabetic foot ulcer
each year, including 1.6 million people in the United States. These ulcers precede 80% of …

Importance Lumbar spinal stenosis is a prevalent and disabling cause of low back and leg
pain in older persons, affecting an estimated 103 million persons worldwide. Most are …

Approximately 6% of adults worldwide have atherosclerosis and thrombosis of the lower
limb arteries (peripheral artery disease (PAD)) and the prevalence is rising. PAD causes leg …

Abstract The Society for Vascular Surgery appropriate use criteria (AUC) for the
management of intermittent claudication were created using the RAND appropriateness …

Resistance training not only can improve or maintain muscle mass and strength, but also
has favorable physiological and clinical effects on cardiovascular disease and risk factors …

Importance Home-based walking exercise interventions are recommended for people with
peripheral artery disease (PAD), but evidence of their efficacy has been mixed. Objective To …

Peripheral artery disease (PAD) poses a great challenge to society, with a growing
prevalence in the upcoming years. Patients in the severe stages of PAD are prone to …

Background: Few effective therapies exist to improve lower extremity muscle pathology and
mobility loss due to peripheral artery disease (PAD), in part because mechanisms …

Muscle necrosis and angiogenesis are two major challenges in the treatment of lower-limb
ischemic diseases. In this study, a triple-functional Sr/Si-containing bioceramic/alginate …

Background Peripheral arterial disease (PAD) is estimated to affect 7% of the adult
population in the United States; however, there is currently little understanding of the key …