Plasmodium parasites responsible for the disease malaria reside within erythrocytes. Inside
this niche host cell, parasites internalize and digest host hemoglobin to source amino acids …

Transition state theory teaches that chemically stable mimics of enzymatic transition states
will bind tightly to their cognate enzymes. Kinetic isotope effects combined with …

Mechanisms of action (MoAs) have been elusive for most antimalarial drugs in clinical use.
Decreasing responsiveness to antimalarial treatments stresses the need for a better …

Intracellular pathogens have devised mechanisms to exploit their host cells to ensure their
survival and replication. The malaria parasite Plasmodium falciparum relies on an exchange …

By lacking de novo purine biosynthesis enzymes, Plasmodium falciparum requires purine
nucleoside uptake from host cells. The indispensable nucleoside transporter ENT1 of P …

A central hub of carbon metabolism is the tricarboxylic acid cycle, which serves to connect
the processes of glycolysis, gluconeogenesis, respiration, amino acid synthesis and other …

For many years, the purine salvage pathway of parasitic protozoa has been regarded as an
attractive chemotherapeutic target. Parasitic protozoa lack de novo synthesis and rely …

Human malaria parasites proliferate in different erythroid cell types during infection. Whilst
Plasmodium vivax exhibits a strong preference for immature reticulocytes, the more …

Malaria still affects around 200 million people and is responsible for more than 400,000
deaths per year, mostly children in subequatorial areas. This disease is caused by parasites …

As it grows and replicates within the erythrocytes of its host the malaria parasite takes up
nutrients from the extracellular medium, exports metabolites and maintains a tight control …