Endoplasmic reticulum stress: its role in disease and novel prospects for therapy
AH Schönthal - Scientifica, 2012 - Wiley Online Library
The endoplasmic reticulum (ER) is a multifunctional organelle required for lipid biosynthesis,
calcium storage, and protein folding and processing. A number of physiological and …
calcium storage, and protein folding and processing. A number of physiological and …
NSAIDs inhibit tumorigenesis, but how?
E Gurpinar, WE Grizzle, GA Piazza - Clinical cancer research, 2014 - AACR
Numerous epidemiologic studies have reported that the long-term use of nonsteroidal anti-
inflammatory drugs (NSAID) is associated with a significant decrease in cancer incidence …
inflammatory drugs (NSAID) is associated with a significant decrease in cancer incidence …
Celecoxib pathways: pharmacokinetics and pharmacodynamics
Background Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID) with anti-
inflammatory, analgestic, and antipyretic properties. It is approved for the treatment of …
inflammatory, analgestic, and antipyretic properties. It is approved for the treatment of …
The ketogenic diet reverses gene expression patterns and reduces reactive oxygen species levels when used as an adjuvant therapy for glioma
P Stafford, MG Abdelwahab, DY Kim, MC Preul… - Nutrition & …, 2010 - Springer
Background Malignant brain tumors affect people of all ages and are the second leading
cause of cancer deaths in children. While current treatments are effective and improve …
cause of cancer deaths in children. While current treatments are effective and improve …
Pharmacological targeting of endoplasmic reticulum stress signaling in cancer
AH Schönthal - Biochemical pharmacology, 2013 - Elsevier
The endoplasmic reticulum (ER) stress response constitutes a cellular process that can be
triggered by a great variety of conditions that cause imbalances in intracellular homeostasis …
triggered by a great variety of conditions that cause imbalances in intracellular homeostasis …
Targeting apoptosis pathways by Celecoxib in cancer
V Jendrossek - Cancer letters, 2013 - Elsevier
Celecoxib is a paradigmatic selective inhibitor of cyclooxygenase-2 (COX-2). This anti-
inflammatory drug has potent anti-tumor activity in a wide variety of human epithelial tumor …
inflammatory drug has potent anti-tumor activity in a wide variety of human epithelial tumor …
COX-independent mechanisms of cancer chemoprevention by anti-inflammatory drugs
E Gurpinar, WE Grizzle, GA Piazza - Frontiers in oncology, 2013 - frontiersin.org
Epidemiological and clinical studies suggest that non-steroidal anti-inflammatory drugs
(NSAIDs), including cyclooxygenase (COX)-2 selective inhibitors, reduce the risk of …
(NSAIDs), including cyclooxygenase (COX)-2 selective inhibitors, reduce the risk of …
Non-steroidal anti-inflammatory drugs increase cisplatin, paclitaxel, and doxorubicin efficacy against human cervix cancer cells
DX Robledo-Cadena, JC Gallardo-Pérez… - Pharmaceuticals, 2020 - mdpi.com
This study shows that the non-steroidal anti-inflammatory drug (NSAID) celecoxib and its
non-cyclooxygenase-2 (COX2) analogue dimethylcelecoxib (DMC) exert a potent inhibitory …
non-cyclooxygenase-2 (COX2) analogue dimethylcelecoxib (DMC) exert a potent inhibitory …
Aggravated endoplasmic reticulum stress as a basis for enhanced glioblastoma cell killing by bortezomib in combination with celecoxib or its non-coxib analogue, 2, 5 …
A Kardosh, EB Golden, P Pyrko, J Uddin, FM Hofman… - Cancer research, 2008 - AACR
The proteasome inhibitor bortezomib (Velcade) is known to trigger endoplasmic reticulum
(ER) stress via the accumulation of obsolete and damaged proteins. The selective …
(ER) stress via the accumulation of obsolete and damaged proteins. The selective …
Calcium-activated endoplasmic reticulum stress as a major component of tumor cell death induced by 2, 5-dimethyl-celecoxib, a non-coxib analogue of celecoxib
P Pyrko, A Kardosh, YT Liu, N Soriano, W Xiong… - Molecular cancer …, 2007 - AACR
A drawback of extensive coxib use for antitumor purposes is the risk of life-threatening side
effects that are thought to be a class effect and probably due to the resulting imbalance of …
effects that are thought to be a class effect and probably due to the resulting imbalance of …