[HTML][HTML] PDGF signaling pathway in hepatic fibrosis pathogenesis and therapeutics

HZ Ying, Q Chen, WY Zhang… - Molecular …, 2017 - … .spandidos-publications.com
The platelet‑derived growth factor (PDFG) signaling pathway exerts persistent activation in
response to a variety of stimuli and facilitates the progression of hepatic fibrosis. Since this …

Fibrotic scar in CNS injuries: from the cellular origins of fibroblasts to the molecular processes of fibrotic scar formation

M Ayazi, S Zivkovic, G Hammel, B Stefanovic, Y Ren - Cells, 2022 - mdpi.com
Central nervous system (CNS) trauma activates a persistent repair response that leads to
fibrotic scar formation within the lesion. This scarring is similar to other organ fibrosis in …

Promoting effect of baicalin on nitric oxide production in CMECs via activating the PI3K-AKT-eNOS pathway attenuates myocardial ischemia–reperfusion injury

J Bai, Q Wang, J Qi, H Yu, C Wang, X Wang, Y Ren… - Phytomedicine, 2019 - Elsevier
Objective Baicalin, which is isolated from Scutellariae Radix, has been shown to possess
therapeutic potential for different diseases. Cardiac microvessel injury in myocardial …

Neuroprotective effect of Dl-3-n-butylphthalide against ischemia–reperfusion injury is mediated by ferroptosis regulation via the SLC7A11/GSH/GPX4 pathway and …

S Xu, X Li, Y Li, X Li, E Lv, X Zhang, Y Shi… - Frontiers in Aging …, 2023 - frontiersin.org
Background Stroke is one of the most severe diseases worldwide, resulting in physical and
mental problems. Dl-3-n-butylphthalide, a compound derived from celery seed, has been …

Platelet‐derived growth factor (PDGF)‐BB protects dopaminergic neurons via activation of Akt/ERK/CREB pathways to upregulate tyrosine hydroxylase

H Chen, Y Teng, X Chen, Z Liu, F Geng… - CNS Neuroscience …, 2021 - Wiley Online Library
Aims The neurotropic growth factor PDGF‐BB was shown to have vital neurorestorative
functions in various animal models of Parkinson's disease (PD). Previous studies indicated …

miR‑320a in serum exosomes promotes myocardial fibroblast proliferation via regulating the PIK3CA/Akt/mTOR signaling pathway in HEH2 cells

QG Wang, BCY Cheng, YZ He… - Experimental and …, 2021 - spandidos-publications.com
MicroRNAs (miRNAs/miRs) serve an important role in the pathogenesis of chronic heart
failure (CHF). A number of reports have illustrated the regulatory effect of serum exosomal …

Allicin improves the function of cardiac microvascular endothelial cells by increasing PECAM-1 in rats with cardiac hypertrophy

P Shi, Y Cao, J Gao, B Fu, J Ren, L Ba, C Song, H Qi… - Phytomedicine, 2018 - Elsevier
Objective Cardiac microvascular damage is significantly associated with the development of
cardiac hypertrophy (CH). Researchers found that allicin could inhibit CH, but the …

[PDF][PDF] The targeted regulation of miR-26a on PTEN-PI3K/AKT signaling pathway in myocardial fibrosis after myocardial infarction.

S Zhang, R Cui - European Review for Medical & …, 2018 - europeanreview.org
OBJECTIVE: MiR-26a is involved in regulating myocardial remodeling and it is also related
to organ fibrosis. Its role in myocardial fibrosis process is still controversy. As a definite target …

Berberine inhibits the ischemia‑reperfusion injury induced inflammatory response and apoptosis of myocardial cells through the phosphoinositide 3‑kinase/RAC‑α …

L Wang, H Ma, Y Xue, H Shi… - Experimental and …, 2018 - spandidos-publications.com
Myocardial ischemia‑reperfusion injury is one of the most common cardiovascular diseases,
and can lead to serious damage and dysfunction of the myocardial tissue. Previous studies …

[HTML][HTML] Ascophyllum nodosum and Fucus vesiculosus ameliorate restenosis via improving inflammation and regulating the PTEN/PI3K/AKT signaling pathway

CN Zumbi, CH Pan, HY Huang, CH Wu - Food Science and Human …, 2024 - Elsevier
Restenosis is a common complication following coronary angioplasty. The traditional use of
seaweeds for health benefits has increasingly been explored, however few studies exist …