COPD is a major cause of death and disability worldwide. Treatment of COPD improves lung
function but is unlikely to slow the steady downhill course of the disease or reduce mortality …

Chronic obstructive pulmonary disease (COPD) affects the lives of an ever-growing number
of people worldwide. The lack of understanding surrounding the pathophysiology of the …

The cells and proteases that mediate cigarette smoke–induced emphysema are
controversial, with evidence favoring either neutrophils and neutrophil-derived serine …

Although cigarette smoking is implicated in the pathogenesis of emphysema, the precise
mechanisms of chronic progressive alveolar septal destruction are not well understood. We …

Emphysema is classically defined by pathologic criteria as destruction of lung parenchyma
distal to the terminal bronchioles without associated inflammation or scarring (1–3). The …

It has been shown that structural changes in small airways of smokers with average smoking
histories greater than 35 pack-years could be reflected in the single-breath washout test …

There is increasing interest in the objective measurement of physical activity in chronic
obstructive pulmonary disease (COPD) patients due to the close relationship between …

Abstract Heme oxygenase-1 (HO-1), an inducible stress protein, confers cytoprotection
against oxidative stress in vitro and in vivo. In addition to its physiological role in heme …

The purpose of this study is to develop a clinical decision support system based on machine
learning (ML) algorithms to help the diagnostic of chronic obstructive pulmonary disease …

Background Chronic obstructive pulmonary disease (COPD) is a common respiratory
disorder for which new diagnostic and therapeutic approaches are required. Hallmarks of …