LAG 3 (CD 223) as a cancer immunotherapy target
LP Andrews, AE Marciscano, CG Drake… - Immunological …, 2017 - Wiley Online Library
Despite the impressive impact of CTLA 4 and PD 1‐PDL 1‐targeted cancer immunotherapy,
a large proportion of patients with many tumor types fail to respond. Consequently, the focus …
a large proportion of patients with many tumor types fail to respond. Consequently, the focus …
Genome-wide analysis identifies NR4A1 as a key mediator of T cell dysfunction
T cells become dysfunctional when they encounter self antigens or are exposed to chronic
infection or to the tumour microenvironment 1. The function of T cells is tightly regulated by a …
infection or to the tumour microenvironment 1. The function of T cells is tightly regulated by a …
Cross-talk between cancer stem cells and immune cells: potential therapeutic targets in the tumor immune microenvironment
B Wu, X Shi, M Jiang, H Liu - Molecular Cancer, 2023 - Springer
Ongoing research has revealed that the existence of cancer stem cells (CSCs) is one of the
biggest obstacles in the current cancer therapy. CSCs make an influential function in tumor …
biggest obstacles in the current cancer therapy. CSCs make an influential function in tumor …
Potential Predictive Value of TP53 and KRAS Mutation Status for Response to PD-1 Blockade Immunotherapy in Lung Adenocarcinoma
ZY Dong, WZ Zhong, XC Zhang, J Su, Z Xie, SY Liu… - Clinical cancer …, 2017 - AACR
Purpose: Although clinical studies have shown promise for targeting programmed cell death
protein-1 (PD-1) and ligand (PD-L1) signaling in non–small cell lung cancer (NSCLC), the …
protein-1 (PD-1) and ligand (PD-L1) signaling in non–small cell lung cancer (NSCLC), the …
[HTML][HTML] Targeting alpha-synuclein as a therapy for Parkinson's disease
CR Fields, N Bengoa-Vergniory… - Frontiers in molecular …, 2019 - frontiersin.org
Parkinson's disease (PD) is one of the most common neurodegenerative disorders with a
global burden of approximately 6.1 million patients. Alpha-synuclein has been linked to both …
global burden of approximately 6.1 million patients. Alpha-synuclein has been linked to both …
Immune checkpoint blockade in infectious diseases
The upregulation of immune checkpoint molecules, such as programmed cell death protein
1 (PD1) and cytotoxic T lymphocyte antigen 4 (CTLA4), on immune cells occurs during acute …
1 (PD1) and cytotoxic T lymphocyte antigen 4 (CTLA4), on immune cells occurs during acute …
Induction and transcriptional regulation of the co-inhibitory gene module in T cells
The expression of co-inhibitory receptors, such as CTLA-4 and PD-1, on effector T cells is a
key mechanism for ensuring immune homeostasis. Dysregulated expression of co-inhibitory …
key mechanism for ensuring immune homeostasis. Dysregulated expression of co-inhibitory …
The spatial landscape of progression and immunoediting in primary melanoma at single-cell resolution
Cutaneous melanoma is a highly immunogenic malignancy that is surgically curable at early
stages but life-threatening when metastatic. Here we integrate high-plex imaging, 3D high …
stages but life-threatening when metastatic. Here we integrate high-plex imaging, 3D high …
Targeting the microenvironment in solid tumors
Tumorigenesis is a complex and dynamic process involving different cellular and non-
cellular elements composed of tumor microenvironment (TME). The interaction of TME with …
cellular elements composed of tumor microenvironment (TME). The interaction of TME with …
Immune checkpoints and their inhibition in cancer and infectious diseases
The development of chronic infections and cancer is facilitated by a variety of immune
subversion mechanisms, such as the production of anti‐inflammatory cytokines, induction of …
subversion mechanisms, such as the production of anti‐inflammatory cytokines, induction of …