The non-coding RNA interactome in joint health and disease
Non-coding RNAs have distinct regulatory roles in the pathogenesis of joint diseases
including osteoarthritis (OA) and rheumatoid arthritis (RA). As the amount of high-throughput …
including osteoarthritis (OA) and rheumatoid arthritis (RA). As the amount of high-throughput …
Epigenetic regulation of chondrocytes and subchondral bone in osteoarthritis
The aim of this review is to provide an updated review of the epigenetic factors involved in
the onset and development of osteoarthritis (OA). OA is a prevalent degenerative joint …
the onset and development of osteoarthritis (OA). OA is a prevalent degenerative joint …
miR‐144‐3p ameliorates the progression of osteoarthritis by targeting IL‐1β: potential therapeutic implications
YY Lin, CY Ko, SC Liu, YH Wang… - Journal of Cellular …, 2021 - Wiley Online Library
The pro‐inflammatory cytokine interleukin 1 beta (IL‐1β) plays a critical role in osteoarthritis
(OA) disease pathogenesis. MicroRNA (miRNA) activity is related to inflammation in OA and …
(OA) disease pathogenesis. MicroRNA (miRNA) activity is related to inflammation in OA and …
Contribution of MicroRNA‐27b‐3p to Synovial Fibrotic Responses in Knee Osteoarthritis
Objective Synovial fibrosis contributes to osteoarthritis (OA) pathology, but the underlying
mechanisms remain unknown. We have observed increased microRNA‐27b‐3p (miR‐27b …
mechanisms remain unknown. We have observed increased microRNA‐27b‐3p (miR‐27b …
The role of genetic polymorphisms of interleukin-1 (IL-1R1 and IL-1RN) in primary knee osteoarthritis in Indonesia
NC Budhiparama, I Lumban-Gaol, H Sudoyo… - Scientific Reports, 2023 - nature.com
This study aimed to evaluate the association of SNPs of the IL-1 family with the clinical
severity of knee OA. This case‒control study was performed among 100 healthy knees and …
severity of knee OA. This case‒control study was performed among 100 healthy knees and …
M2 Macrophages Promote PDGFRβ+ Pericytes Migration After Spinal Cord Injury in Mice via PDGFB/PDGFRβ Pathway
Z Li, M Zheng, S Yu, F Yao, Y Luo, Y Liu… - Frontiers in …, 2021 - frontiersin.org
Platelet derived growth factor receptor β positive (PDGFRβ+) pericytes form fibrotic scar,
which prevents axonal regeneration after spinal cord injury (SCI). However, the mechanism …
which prevents axonal regeneration after spinal cord injury (SCI). However, the mechanism …
MicroRNA-10a-3p improves cartilage degeneration by regulating CH25H-CYP7B1-RORα mediated cholesterol metabolism in knee osteoarthritis rats
X Li, L Zhang, X Shi, T Liao, N Zhang, Y Gao… - Frontiers in …, 2021 - frontiersin.org
Osteoarthritis (OA) is a worldwide degenerative joint disease that seriously impaired the
quality of life of patients. OA has been established as a disease with metabolic disorder …
quality of life of patients. OA has been established as a disease with metabolic disorder …
Circulating miR-146b and miR-27b are efficient biomarkers for early diagnosis of Equidae osteoarthritis
One of the most orthopedic problems seen in the equine is osteoarthritis (OA). The present
study tracks some biochemical, epigenetic, and transcriptomic factors along different stages …
study tracks some biochemical, epigenetic, and transcriptomic factors along different stages …
Identification of SCRG1 as a potential therapeutic target for human synovial inflammation
G Liu, G He, J Zhang, Z Zhang, L Wang - Frontiers in Immunology, 2022 - frontiersin.org
Synovial inflammation of joint tissue is the most important cause of tissue damage, joint
destruction, and disability and is associated with higher morbidity or mortality. Therefore, this …
destruction, and disability and is associated with higher morbidity or mortality. Therefore, this …
Osteoarthritis related epigenetic variations in miRNA expression and DNA methylation
L Jin, J Ma, Z Chen, F Wang, Z Li, Z Shang… - BMC Medical …, 2023 - Springer
Osteoarthritis (OA) is chronic arthritis characterized by articular cartilage degradation.
However, a comprehensive regulatory network for OA-related microRNAs and DNA …
However, a comprehensive regulatory network for OA-related microRNAs and DNA …