The non-coding RNA interactome in joint health and disease

SA Ali, MJ Peffers, MJ Ormseth, I Jurisica… - Nature Reviews …, 2021 - nature.com
Non-coding RNAs have distinct regulatory roles in the pathogenesis of joint diseases
including osteoarthritis (OA) and rheumatoid arthritis (RA). As the amount of high-throughput …

Epigenetic regulation of chondrocytes and subchondral bone in osteoarthritis

HC Ball, AL Alejo, TK Samson, AM Alejo, FF Safadi - Life, 2022 - mdpi.com
The aim of this review is to provide an updated review of the epigenetic factors involved in
the onset and development of osteoarthritis (OA). OA is a prevalent degenerative joint …

miR‐144‐3p ameliorates the progression of osteoarthritis by targeting IL‐1β: potential therapeutic implications

YY Lin, CY Ko, SC Liu, YH Wang… - Journal of Cellular …, 2021 - Wiley Online Library
The pro‐inflammatory cytokine interleukin 1 beta (IL‐1β) plays a critical role in osteoarthritis
(OA) disease pathogenesis. MicroRNA (miRNA) activity is related to inflammation in OA and …

Contribution of MicroRNA‐27b‐3p to Synovial Fibrotic Responses in Knee Osteoarthritis

G Tavallaee, S Lively, JS Rockel, SA Ali… - Arthritis & …, 2022 - Wiley Online Library
Objective Synovial fibrosis contributes to osteoarthritis (OA) pathology, but the underlying
mechanisms remain unknown. We have observed increased microRNA‐27b‐3p (miR‐27b …

The role of genetic polymorphisms of interleukin-1 (IL-1R1 and IL-1RN) in primary knee osteoarthritis in Indonesia

NC Budhiparama, I Lumban-Gaol, H Sudoyo… - Scientific Reports, 2023 - nature.com
This study aimed to evaluate the association of SNPs of the IL-1 family with the clinical
severity of knee OA. This case‒control study was performed among 100 healthy knees and …

M2 Macrophages Promote PDGFRβ+ Pericytes Migration After Spinal Cord Injury in Mice via PDGFB/PDGFRβ Pathway

Z Li, M Zheng, S Yu, F Yao, Y Luo, Y Liu… - Frontiers in …, 2021 - frontiersin.org
Platelet derived growth factor receptor β positive (PDGFRβ+) pericytes form fibrotic scar,
which prevents axonal regeneration after spinal cord injury (SCI). However, the mechanism …

MicroRNA-10a-3p improves cartilage degeneration by regulating CH25H-CYP7B1-RORα mediated cholesterol metabolism in knee osteoarthritis rats

X Li, L Zhang, X Shi, T Liao, N Zhang, Y Gao… - Frontiers in …, 2021 - frontiersin.org
Osteoarthritis (OA) is a worldwide degenerative joint disease that seriously impaired the
quality of life of patients. OA has been established as a disease with metabolic disorder …

Circulating miR-146b and miR-27b are efficient biomarkers for early diagnosis of Equidae osteoarthritis

AM Yassin, HO AbuBakr, AI Abdelgalil, OA Farid… - Scientific reports, 2023 - nature.com
One of the most orthopedic problems seen in the equine is osteoarthritis (OA). The present
study tracks some biochemical, epigenetic, and transcriptomic factors along different stages …

Identification of SCRG1 as a potential therapeutic target for human synovial inflammation

G Liu, G He, J Zhang, Z Zhang, L Wang - Frontiers in Immunology, 2022 - frontiersin.org
Synovial inflammation of joint tissue is the most important cause of tissue damage, joint
destruction, and disability and is associated with higher morbidity or mortality. Therefore, this …

Osteoarthritis related epigenetic variations in miRNA expression and DNA methylation

L Jin, J Ma, Z Chen, F Wang, Z Li, Z Shang… - BMC Medical …, 2023 - Springer
Osteoarthritis (OA) is chronic arthritis characterized by articular cartilage degradation.
However, a comprehensive regulatory network for OA-related microRNAs and DNA …