The intestinal mucosa provides a selective permeable barrier for nutrient absorption and
protection from external factors. It consists of epithelial cells, immune cells and their …

Although intermittent increases in inflammation are critical for survival during physical injury
and infection, recent research has revealed that certain social, environmental and lifestyle …

Objective The microbiome directly affects the balance of pro-inflammatory and anti-
inflammatory responses in the gut. As microbes thrive on dietary substrates, the question …

Diet-induced metabolic endotoxemia is an important factor in the development of many
chronic diseases in animals and man. The gut epithelium is an efficient barrier that prevents …

Background: Whether the positive associations of smoking and alcohol consumption with
gastrointestinal diseases are causal is uncertain. We conducted this Mendelian …

An understanding of connections between gut microbiome and liver has provided important
insights into the pathophysiology of liver diseases. Since gut microbial dysbiosis increases …

Alcohol is inextricably linked with the digestive system. It is absorbed through the gut and
metabolised by hepatocytes within the liver. Excessive alcohol use results in alterations to …

At-risk alcohol use is a major contributor to the global health care burden and leads to
preventable deaths and diseases including alcohol addiction, alcoholic liver disease …

Colorectal cancer (CRC) is a major cause of morbidity and mortality, being the third most
common cancer diagnosed in both men and women in the world. Several environmental …

Damage to the tissue and the ruining of functions characterize autoimmune syndromes. This
review centers around leaky gut syndromes and how they stimulate autoimmune …