Objectives Perivascular spaces have been involved in neuroinflammatory and
neurodegenerative diseases. Upon a certain size, these spaces can become visible on …

The cerebral waste clearance system (ie, glymphatic or intramural periarterial drainage)
works through a network of perivascular spaces (PVS). Dysfunction of this system likely …

Background Alzheimer's disease (AD) is highly intertwined with sleep disturbances
throughout its whole natural history. Sleep consists of a major compound of the functionality …

Perivascular spaces (PVS) are fluid-filled compartments that dilate in response to many
different conditions. A high burden of enlarged PVS (EPVS) in the centrum semiovale (CSO) …

Epidemiological evidence demonstrates a link between air pollution exposure and the onset
and progression of cognitive impairment and Alzheimer's disease (AD). However, current …

BACKGROUND AND PURPOSE: Cerebral amyloid angiopathy is characterized by amyloid
β deposition in leptomeningeal and superficial cortical vessels. Cognitive impairment is …

Background Glymphatic dysfunction is a crucial pathway for dementia. Alzheimer's disease
(AD) pathologies co-existing with cerebral small vessel disease (CSVD) is the most common …

The neurovascular unit (NVU) is a complex structure that facilitates nutrient delivery and
metabolic waste clearance, forms the blood–brain barrier (BBB), and supports fluid …

In the brain, perivascular fibroblasts (PVFs) reside within the perivascular spaces (PVSs) of
arterioles and large venules, however their physiological and pathophysiological roles …

Stroke is one of the most common causes of acquired epilepsy, which can also result in
disability and increased mortality rates particularly in elderly patients. No preventive …