Pyroptosis: mechanisms and diseases

P Yu, X Zhang, N Liu, L Tang, C Peng… - Signal transduction and …, 2021 - nature.com
Currently, pyroptosis has received more and more attention because of its association with
innate immunity and disease. The research scope of pyroptosis has expanded with the …

Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression

C Xue, G Li, J Lu, L Li - Signal transduction and targeted therapy, 2021 - nature.com
Circular RNAs (circRNAs), covalently closed noncoding RNAs, are widely expressed in
eukaryotes and viruses. They can function by regulating target gene expression, linear RNA …

Extracellular vesicle and particle biomarkers define multiple human cancers

A Hoshino, HS Kim, L Bojmar, KE Gyan, M Cioffi… - Cell, 2020 - cell.com
There is an unmet clinical need for improved tissue and liquid biopsy tools for cancer
detection. We investigated the proteomic profile of extracellular vesicles and particles …

[HTML][HTML] Pharmacological basis and new insights of taxifolin: A comprehensive review

A Das, R Baidya, T Chakraborty, AK Samanta… - Biomedicine & …, 2021 - Elsevier
The pharmacological characteristics of phytochemicals have prompted a lot of interest in
their application in disease management. Due to the high incidence of cancer related …

Signal pathways and precision therapy of small-cell lung cancer

M Yuan, Y Zhao, HT Arkenau, T Lao, L Chu… - Signal transduction and …, 2022 - nature.com
Small-cell lung cancer (SCLC) encounters up 15% of all lung cancers, and is characterized
by a high rate of proliferation, a tendency for early metastasis and generally poor prognosis …

METTL3 promotes lung adenocarcinoma tumor growth and inhibits ferroptosis by stabilizing SLC7A11 m6A modification

Y Xu, D Lv, C Yan, H Su, X Zhang, Y Shi, K Ying - Cancer cell international, 2022 - Springer
Abstract Background N6-methyladenosine (m6A) has emerged as a significant regulator of
the progress of various cancers. However, its role in lung adenocarcinoma (LUAD) remains …

Genetic markers in lung cancer diagnosis: a review

K Wadowska, I Bil-Lula, Ł Trembecki… - International journal of …, 2020 - mdpi.com
Lung cancer is the most often diagnosed cancer in the world and the most frequent cause of
cancer death. The prognosis for lung cancer is relatively poor and 75% of patients are …

Tumor organoids: synergistic applications, current challenges, and future prospects in cancer therapy

J Qu, FS Kalyani, L Liu, T Cheng… - Cancer …, 2021 - Wiley Online Library
Patient‐derived cancer cells (PDCs) and patient‐derived xenografts (PDXs) are often used
as tumor models, but have many shortcomings. PDCs not only lack diversity in terms of cell …

Liquid biopsy for lung cancer: up-to-date and perspectives for screening programs

GMS Casagrande, MO Silva, RM Reis… - International Journal of …, 2023 - mdpi.com
Lung cancer is the deadliest cancer worldwide. Tissue biopsy is currently employed for the
diagnosis and molecular stratification of lung cancer. Liquid biopsy is a minimally invasive …

PPAR-α modulators as current and potential cancer treatments

Y Tan, M Wang, K Yang, T Chi, Z Liao, P Wei - Frontiers in oncology, 2021 - frontiersin.org
Cancer is one of the leading causes of mortality worldwide. PPAR modulators may hold
great potential for the management of cancer patients. Indeed, PPARs are critical sensors …