Endothelin-1 gene polymorphism (G8002A) and endothelial monocyte-activating polypeptide II: Role in vascular dysfunction in pediatric patients with β-thalassemia …

AAG Tantawy, MAR Tadros, AAM Adly, EAR Ismail… - Cytokine, 2023 - Elsevier
Abstract Background: Endothelin-1 (ET-1), a potent endogenous vasoconstrictor, stimulates
production of reactive oxygen species. Endothelial monocyte-activating polypeptide-II …

Protein antioxidants in thalassemia

S Awadallah - Advances in clinical chemistry, 2013 - Elsevier
It is common knowledge that thalassemic patients are under significant oxidative stress.
Chronic hemolysis, frequent blood transfusion, and increased intestinal absorption of iron …

[HTML][HTML] Lipids profile in children and adolescents with β-thalassemia major

HK Jabbar, MK Hassan, LM Al-Naama - Hematology, Transfusion and …, 2023 - SciELO Brasil
Introduction: Patients with β-thalassemia major (β-TM) are at risk of developing abnormal
lipid profiles. Lipid abnormalities, in turn, have a potential role in the pathogenesis of some …

Ferric citrate CYP2E1-independently promotes alcohol-induced apoptosis in HepG2 cells via oxidative/nitrative stress which is attenuated by pretreatment with …

Y Xu, Y Feng, H Li, Z Gao - Food and chemical toxicology, 2012 - Elsevier
In the case of alcoholic liver injury, an iron overload is always present. Both alcohol and iron
can individually induce oxidative stress in liver. However, the combined effect of …

[HTML][HTML] Role of malonaldehyde as a surrogate biomarker for iron overload in the β-thalassemia patient: A systematic meta-analysis

D Basu, DG Adhya, R Sinha, N Chakravorty - Advances in Redox Research, 2021 - Elsevier
Malonaldehyde (MDA), a biomarker of oxidative stress is found to be increased in many
individuals suffering from β-thalassemia. This may possibly be attributed to iron overload …

[引用][C] 铁过载组织损伤特点及机制研究进展

黄蕾, 付蓉, 邵宗鸿 - 中华血液学杂志, 2012

[HTML][HTML] Status of superoxide dismutase in transfusion dependent thalassaemia

L Rujito, S Mulatsih, ASM Sofro - North American journal of medical …, 2015 - ncbi.nlm.nih.gov
Background: Thalassemia is a collection of genetic impairments in beta and alpha genes
causing various states of anemia. Severe types of the disease need lifelong transfusions …

Effect of antioxidant therapy on hepatic fibrosis and liver iron concentrations in β-thalassemia major patients

MS Elalfy, AAM Adly, AAM Attia, FA Ibrahim… - …, 2013 - Taylor & Francis
To assess the effects of combined vitamin therapy on oxidant-antioxidant hepatic status and
hemoglobin (Hb) derivatives on β-thalassemia major (β-TM), a prospective study of 60 β-TM …

Zinc improved erythrocyte deformability and aggregation in patients with beta-thalassemia: An in vitro study

M Sinan, O Yalcin, Z Karakas… - Clinical …, 2023 - content.iospress.com
BACKGROUND: Thalassemia patients have reduced red cell deformability and decreased
plasma zinc levels in their blood. OBJECTIVE: This study aimed to evaluate the effects of …

[PDF][PDF] Molecular and biochemical study on β-thalassemia patients in Iraq

AM Saud - University of Baghdad, 2012 - researchgate.net
First, a special gratitude and thanks are due to “Allah” for his entire blessing during the
pursuit of my academic career goals. I would like to express my deepest appreciation and …