Trial watch: chemotherapy-induced immunogenic cell death in oncology

J Sprooten, RS Laureano, I Vanmeerbeek… - …, 2023 - Taylor & Francis
Immunogenic cell death (ICD) refers to an immunologically distinct process of regulated cell
death that activates, rather than suppresses, innate and adaptive immune responses. Such …

Immunogenic cell death in cancer: targeting necroptosis to induce antitumour immunity

P Meier, AJ Legrand, D Adam, J Silke - Nature Reviews Cancer, 2024 - nature.com
Most metastatic cancers remain incurable due to the emergence of apoptosis-resistant
clones, fuelled by intratumour heterogeneity and tumour evolution. To improve treatment …

Exploring nanocarriers as innovative materials for advanced drug delivery strategies in onco-immunotherapies

P Tiwari, RP Shukla, K Yadav, D Panwar… - Journal of Molecular …, 2024 - Elsevier
In recent years, Onco-immunotherapies (OIMTs) have been shown to be a potential therapy
option for cancer. Several immunotherapies have received regulatory approval, while many …

The mechanism and clinical application of DNA damage repair inhibitors combined with immune checkpoint inhibitors in the treatment of urologic cancer

D Xie, B Jiang, S Wang, Q Wang, G Wu - Frontiers in Cell and …, 2023 - frontiersin.org
Urologic cancers such as kidney, bladder, prostate, and uroepithelial cancers have recently
become a considerable global health burden, and the response to immunotherapy is limited …

Extracellular vesicles-powered immunotherapy: Unleashing the potential for safer and more effective cancer treatment

P Tiwari, K Yadav, RP Shukla, AK Bakshi… - Archives of Biochemistry …, 2024 - Elsevier
Cancer treatment has seen significant advancements with the introduction of Onco-
immunotherapies (OIMTs). Although some of these therapies have received approval for …

Tumor cell membrane‐based vaccines: a potential boost for cancer immunotherapy

M Yang, J Zhou, L Lu, D Deng, J Huang, Z Tang… - …, 2024 - Wiley Online Library
Because therapeutic cancer vaccines can, in theory, eliminate tumor cells specifically with
relatively low toxicity, they have long been considered for application in repressing cancer …

Label-Free Multiplex Profiling of Exosomal Proteins with a Deep Learning-Driven 3D Surround-Enhancing SERS Platform for Early Cancer Diagnosis

M Chen, H Wang, Y Zhang, H Jiang, T Li, L Liu… - Analytical …, 2024 - ACS Publications
Identification of protein profiling on plasma exosomes by SERS can be a promising strategy
for early cancer diagnosis. However, it is still challenging to detect multiple exosomal …

The one-two punch: TIM-3 blockade targets immune and tumor cells to knock out pediatric brain tumors

J Lee, JD Lathia - Cancer Cell, 2023 - cell.com
Diffuse midline gliomas (DMGs) pose treatment challenges due to their location within the
brainstem and invasive nature. Although classical immune checkpoint inhibitors have …

Exploiting cell death and tumor immunity in cancer therapy: challenges and future directions

J Lu, R He, Y Liu, J Zhang, H Xu, T Zhang… - Frontiers in Cell and …, 2024 - frontiersin.org
Cancer remains a significant global challenge, with escalating incidence rates and a
substantial burden on healthcare systems worldwide. Herein, we present an in-depth …

Promotion of ICD via Nanotechnology

Y Qin, H Zhang, Y Li, T Xie, S Yan… - Macromolecular …, 2023 - Wiley Online Library
Immunotherapy represents the most promising treatment strategy for cancer, but suffers from
compromised therapeutic efficiency due to low immune activity of tumor cells and an …