Kidney organoids are three-dimensional structures generated from pluripotent stem cells
(PSCs) that are capable of recapitulating the major structures of mammalian kidneys. As this …

The regulation of mineral homeostasis involves the three mineralotropic hormones PTH,
FGF23 and 1, 25-dihydroxyvitamin D3 (1, 25 (OH) 2D3). Early research efforts focused on …

The proximal tubule is the high-capacity reabsorptive powerhouse of the kidney. Two papers
in recent issues of the JCI highlight mechanisms of more delicate effects of the proximal …

The salt-inducible kinases (SIK) 1–3 are key regulators of pro-versus anti-inflammatory
cytokine responses during innate immune activation. The lack of highly SIK-family or SIK …

The rising prevalence of kidney diseases urges the need for novel therapies. Kidney
organoids and tubuloids are advanced in vitro models and have recently been described as …

The clear cell renal cell carcinoma (ccRCC) spotlighted the poorest survival, while
chromophobe renal cell carcinoma (chRCC) was associated with the best survival. Earlier …

Purpose of review: Mineral and bone disorder (MBD) is a prevalent complication in chronic
kidney disease (CKD), significantly impacting overall health with multifaceted implications …

Compartmentalization of GPCR signaling is an emerging topic that highlights the
physiological relevance of spatial bias in signaling. The parathyroid hormone (PTH) type 1 …

Vitamin C, also known as ascorbic acid, is an essential nutrient that plays a critical role in
many physiological processes in plants and animals. In humans, vitamin C is an antioxidant …

Alveolar bone serves to support and anchor teeth. It differs from most other skeletal tissue
due to its unique origin from neural crest-derived mesenchymal cells and its formation …