Ghrelin is a physiological regulator of insulin release in pancreatic islets and glucose homeostasis

K Dezaki, H Sone, T Yada - Pharmacology & therapeutics, 2008 - Elsevier
Ghrelin, an acylated 28-amino acid peptide, was isolated from the stomach as the
endogenous ligand for the growth hormone (GH) secretagogue receptor (GHS-R) …

AMPK signaling to acetyl-CoA carboxylase is required for fasting-and cold-induced appetite but not thermogenesis

S Galic, K Loh, L Murray-Segal, GR Steinberg… - Elife, 2018 - elifesciences.org
AMP-activated protein kinase (AMPK) is a known regulator of whole-body energy
homeostasis, but the downstream AMPK substrates mediating these effects are not entirely …

Ghrelin: more than a natural GH secretagogue and/or an orexigenic factor

E Ghigo, F Broglio, E Arvat, M Maccario… - Clinical …, 2005 - Wiley Online Library
Ghrelin, an acylated peptide produced predominantly by the stomach, has been discovered
to be a natural ligand of the growth hormone secretagogue receptor type 1a (GHS‐R1a) …

Ghrelin: a new player in the control of gastrointestinal functions

TL Peeters - Gut, 2005 - gut.bmj.com
Ghrelin is the endogenous ligand for the growth hormone secretagogue receptor (GHS-R),
present on pituitary cells secreting growth hormone. Ghrelin and motilin, and GHS-R and the …

Obesity, metabolic syndrome, and cardiovascular disease

Y Aggoun - Pediatric research, 2007 - nature.com
Early childhood overweight and obesity have alarmingly increased over the years.
Adulthood obesity is a well demonstrated significant independent predictor of cardiovascular …

Ghrelin, des-acyl ghrelin and nesfatin-1 in gastric X/A-like cells: role as regulators of food intake and body weight

A Stengel, M Goebel, L Wang, Y Taché - Peptides, 2010 - Elsevier
Numerous peptides released from endocrine cells in the intestinal mucosa were established
early on to be involved in the physiological regulation of food intake with a prominent role in …

Ghrelin, the peripheral hunger hormone

SC Higgins, M Gueorguiev, M Korbonits - Annals of medicine, 2007 - Taylor & Francis
In the current review we summarize the available data concerning the gastric hormone
ghrelin and its receptor. Ghrelin stimulates short‐term food intake and long‐term body …

Gut hormones: implications for the treatment of obesity

MT Neary, RL Batterham - Pharmacology & Therapeutics, 2009 - Elsevier
Bariatric surgery is the only effective treatment for patients with morbid obesity. This is no
solution to the present obesity pandemic however. Currently licensed non-surgical …

Physiological, pathological and potential therapeutic roles of ghrelin

AF Leite-Moreira, JB Soares - Drug discovery today, 2007 - Elsevier
Ghrelin, a hormone that is produced mainly by the stomach, was identified originally as the
endogenous ligand of the growth hormone secretagogue (GHS) receptor. Ghrelin might also …

The future role of gut hormones in the treatment of obesity

RC Troke, TM Tan, SR Bloom - Therapeutic advances in …, 2014 - journals.sagepub.com
The obesity pandemic presents a significant burden, both in terms of healthcare and
economic outcomes, and current medical therapies are inadequate to deal with this …