To gain further insight into the regulatory role of insulin and leptin on plasma ghrelin, 56
normal weight, 128 normoinsulinemic obese, 121 hyperinsulinemic obese, and 30 type 2 …

GH secretagogue receptor (GHSR, ghrelin receptor) is involved in regulation of body weight
and GH secretion. We initially analyzed two single-nucleotide polymorphisms of the GHSR …

Objective: Ghrelin is a novel gastric hormone recognized in 1999 as a mediator of growth
hormone release. Since growth hormone is anabolic, an important function of ghrelin may …

G protein-coupled receptors (GPCRs) are the largest family of membrane receptors involved
in the regulation of almost all known physiological processes. Dysfunctions of GPCR …

Peptides may represent potential treatment options for many severe illnesses. However,
they need an effective delivery system to overcome rapid degradation after their …

Background: The current therapies for alcohol abuse disorders are not effective in all
patients, and continued development of pharmacotherapies is needed. One approach that …

BACKGROUND: Ghrelin, an endogenous ligand for growth hormone secretagogue receptor
(GHS-R), is known to increase food intake in lean humans and rodents. In addition, ghrelin …

Ghrelin, an acylated peptide secreted from the stomach, acts as a short-term signal of
nutrient depletion. Ghrelin is an endogenous ligand for the GH secretagogue receptor 1a, a …

There is increasing evidence of the coupling of immune status to the metabolic system. The
communication between the state of systemic and cellular energy balance to immune …

Employing in vitro selection techniques, we have generated biostable RNA-based
compounds, so-called Spiegelmers, that specifically bind n-octanoyl ghrelin, the recently …