Intranasal administration has gained an increasing interest for brain drug delivery since it
allows direct transport through neuronal pathways, which can be quite advantageous for …

Nanomedicine is currently focused on the design and development of nanocarriers that
enhance drug delivery to the brain to address unmet clinical needs for treating …

The Janus kinase-signal transducer and transcription activator pathway (JAK-STAT) serves
as a cornerstone in cellular signaling, regulating physiological and pathological processes …

Mental illnesses including anxiety disorders, autism spectrum disorder, post-traumatic stress
disorder, schizophrenia, depression, and others exact an immense toll on the healthcare …

Prolonged exposure (PE) therapy aiming to promote fear extinction is a useful treatment for
post-traumatic stress disorder (PTSD). However, the mechanisms underlying fear extinction …

In recent years, there have been a growing number of small and large molecules that could
be used to treat diseases of the central nervous system (CNS). Nose-to-brain delivery can …

Ketamine and its enantiomers represent an innovative glutamatergic agent as a treatment
for individuals with treatment-resistant depression (TRD) and major depressive disorder …

Background: Severe dental phobia or failure to cooperate with treatment are very common in
outpatient pediatric dentistry. Personalized and appropriate noninvasive anesthesia …

Diffuse midline glioma (DMG), including tumors diagnosed in the brainstem (diffuse intrinsic
pontine glioma-DIPG), is the primary cause of brain tumor-related death in pediatric patients …

Background In the last few decades, nose-to-brain delivery has been investigated as an
alternative route to deliver molecules to the Central Nervous System (CNS), bypassing the …