As a transcription factor, STAT3 protein transduces extracellular signals to the nucleus and
then activates transcription of target genes. STAT3 has been well validated as an attractive …

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcriptional factor (TF) that is a
member of the Per-Arnt-Sim family of proteins. AhR regulates diverse processes, including …

The aryl hydrocarbon receptor (AhR) is a nuclear protein which, upon association with
certain endogenous and exogenous ligands, translocates into the nucleus, binds DNA and …

Assumptions that liver immune cells and immunosuppressive pathways are similar to their
counterparts in other spaces have led to gaps in our understanding of intrahepatic neoplasm …

Based on high quality surgery and scientific data, scientists and surgeons are committed to
protecting patients as well as healthcare staff and hereby provide this Guidance to address …

Cancer immunotherapy has made impressive advances in improving the outcome of
patients affected by malignant diseases. Nonetheless, some limitations still need to be …

Metabolism of the essential amino acid tryptophan is a key metabolic pathway that restricts
antitumor immunity and is a drug development target for cancer immunotherapy. Tryptophan …

Simple Summary Natural killer cells are able to effectively eliminate tumor cells without
previous sensitization, therefore the interest in their application in tumor immunotherapy has …

Increasing epidemiological and animal experimental data provide substantial support for the
role of aryl hydrocarbon receptor (AhR) in mammary tumorigenesis. The effects of AhR have …

The gut microbiome provides the host access to otherwise indigestible nutrients, which are
often further metabolized by the microbiome into bioactive components. The gut microbiome …