Quinoline is an efficient scaffold for anticancer drug development as its derivatives have
shown potent results through several mechanisms like growth regulators through “apoptosis …

The drug resistance and low specificity of current available chemotherapeutics to cancer
cells are the main reasons responsible for the failure of cancer chemotherapy and remain …

Fragment based drug discovery has long been used for the identification of new ligands and
interest in targeted covalent inhibitors has continued to grow in recent years, with high …

To activate dimethyl sulfoxide (DMSO, CH3SOCH3) as a methylation agent in the C–H
functionalization of (iso) quinoliniums (1), a heterogeneous photo-Fenton-like method …

Quinoline is a versatile heterocycle that is part of numerous natural products and countless
drugs. During the last decades, this scaffold also became widely used as ligand in …

Metal-based complexes have occupied a pioneering niche in the treatment of many chronic
diseases, including various types of cancers. Despite the phenomenal success of cisplatin …

Aiming to discover novel antifungal agents, a series of 2‑substituted‑4‑amino-quinolines and-
quinazoline were prepared and characterized using IR, 1 H NMR, 13 C NMR, and HRMS …

An elegant approach to unknown secosteroid–quinoline hybrids is disclosed. A series of 13,
17-secoestra-1, 3, 5 (10)-trien-17-oic acid [N′-(iso) quinolylmethylene] hydrazides was …

Quinoline and quinazoline alkaloids, two important classes of N-based heterocyclic
compounds, have attracted scientific and popular interest worldwide since the 19th century …

Five new series of pyrrolo-fused heterocycles were designed through a scaffold
hybridization strategy as analogs of the well-known microtubule inhibitor phenstatin …