Hypomyelinating leukodystrophies constitute a subset of genetic white matter disorders
characterized by a primary lack of myelin deposition. Most patients with severe …

The ability to measure myelin in vivo has great consequences for furthering our knowledge
of normal development, as well as for understanding a wide range of neurological disorders …

Myelin is important for the normal development and healthy function of the nervous system.
Recent developments in MRI acquisition and tissue modeling aim to provide a better …

Over the past few decades, MRI-based visualization of demyelinated CNS lesions has
become pivotal to the diagnosis and monitoring of multiple sclerosis (MS). In this Review, we …

Objective Transplanted neural stem/precursor cells (NPCs) display peculiar therapeutic
plasticity in vivo. Although the replacement of cells was first expected as the prime …

Hypomyelinating leukodystrophies represent a genetically heterogeneous but clinically
overlapping group of heritable disorders. Current management approaches in the care of …

Cross-relaxation imaging (CRI) is a quantitative magnetic resonance technique that
measures the kinetic parameters of magnetization transfer between protons bound to water …

Identification of remyelination is important in the evaluation of potential treatments of
demyelinating diseases such as multiple sclerosis. Local injection of lysolecithin into the …

Objectives Investigating the potential of myelin repair strategies in multiple sclerosis (MS)
requires an understanding of myelin dynamics during lesion evolution. The objective of this …

Magnetization transfer (MT) imaging quantitatively assesses cerebral white matter disease
through its sensitivity to macromolecule-bound protons including those associated with …