The discovery of the growth hormone (GH)-mediated somatic factors (somatomedins),
insulin-like growth factor (IGF)-I and-II, has elicited an enormous interest primarily among …

Cell signaling does not apparently occur randomly over the cell surface, but it seems to be
integrated very often into cholesterol-rich membrane domains, termed lipid rafts. Membrane …

The insulin-like growth factors (IGFs) are mitogens that play a pivotal role in regulating cell
proliferation, differentiation, and apoptosis. The effects of IGFs are mediated through the IGF …

Insulin‐like growth factors (IGFs) are essential for growth and survival that suppress
apoptosis and promote cell cycle progression, angiogenesis, and metastatic activities in …

Uterine leiomyomas, or fibroids, represent a major public health problem. It is believed that
these tumors develop in the majority of American women and become symptomatic in one …

Melanoma originates in the epidermis and becomes metastatic after invasion into the
dermis. Prior interactions between melanoma cells and dermis are poorly studied. Here, we …

Interest in insulin-like growth factors (IGFs) and their effect on carcinogenesis has increased
recently because high serum concentrations of IGF1 are associated with an increased risk of …

The IGF system components have been implicated in breast cancer progression. IGF-I and
IGF-II are mitogenic and anti-apoptotic peptides that influence the proliferation of various cell …

The two members of the P-type lectin family, the cation-dependent mannose 6-phosphate
receptor (CD-MPR) and the insulin-like growth factor II/mannose 6-phosphate receptor (IGF …

In contrast to the biallelic expression of most genes, expression of genes subject to genomic
imprinting is monoallelic and based on the sex of the transmitting parent. Possession of only …