Diabetic foot ulcers (DFUs) are associated with complex pathogenic factors and are
considered a serious complication of diabetes. The potential mechanisms underlying DFUs …

Diabetic wounds often have a slow healing process and become easily infected owing to
hyperglycemia in wound beds. Once planktonic bacterial cells develop into biofilms, the …

Neovascularization is critical to improve the diabetic microenvironment, deliver abundant
nutrients to the wound and promote wound closure. However, the excess of oxidative stress …

Chronic wounds in diabetes undergo a lifetime risk of developing into diabetic foot ulcers.
Oxygen is crucial to wound healing by regulating cell proliferation, migration, and …

Oxygen plays an important role in diabetic chronic wound healing by regulating various life
activities such as cell proliferation, migration, and angiogenesis. Therefore, oxygen …

Background Diabetic foot ulceration is a serious chronic complication of diabetes mellitus
characterized by high disability, mortality, and morbidity. Platelet-rich plasma (PRP) has …

Inadequate angiogenesis and inflammation at the wound site have always been a major
threat to skin wounds, especially for diabetic wounds that are difficult to heal. Therefore …

The final outcome of diabetes is chronic complications, of which vascular complications are
the most serious, which is the main cause of death for diabetic patients and the direct cause …

Notch pathway is an evolutionarily conserved signalling system that operates to influence an
astonishing array of cell fate decisions in different developmental contexts. Notch signalling …

Chronic inflammation and hypoxia in the microenvironment of diabetic foot ulcers (DFUs)
can result in sustained vascular impairment, hindering tissue regeneration. While both nitric …