Copper, gallium and zirconium positron emission tomography imaging agents: The importance of metal ion speciation

LE McInnes, SE Rudd, PS Donnelly - Coordination Chemistry Reviews, 2017 - Elsevier
Positron emission tomography (PET) is a medical diagnostic imaging technique that
requires administration of a β+-emitting radiotracer to a patient. Metal-based PET …

Non-invasive radionuclide imaging of trace metal trafficking in health and disease:“PET metallomics”

G Firth, JE Blower, JJ Bartnicka, A Mishra… - RSC Chemical …, 2022 - pubs.rsc.org
Several specific metallic elements must be present in the human body to maintain health
and function. Maintaining the correct quantity (from trace to bulk) and location at the cell and …

68Ga-radiolabeled bombesin-conjugated to trimethyl chitosan-coated superparamagnetic nanoparticles for molecular imaging: preparation, characterization and …

M Hajiramezanali, F Atyabi, M Mosayebnia… - International journal …, 2019 - Taylor & Francis
Introduction Nowadays, nanoparticles (NPs) have attracted much attention in biomedical
imaging due to their unique magnetic and optical characteristics. Superparamagnetic iron …

Engineering a modular 44Ti/44Sc generator: eluate evaluation in preclinical models and estimation of human radiation dosimetry

N Benabdallah, H Zhang, R Unnerstall, A Fears… - EJNMMI research, 2023 - Springer
Abstract Background 44Sc/47Sc is an attractive theranostic pair for targeted in vivo positron
emission tomographic (PET) imaging and beta-particle treatment of cancer. The 44Ti/44Sc …

Direct and indirect chimeric antigen receptor T-Cell imaging with PET/MRI in a tumor xenograft model

SY Kim, H Soh, JH Jung, EH Cho, H Kim, JM Ju… - Radiology, 2024 - pubs.rsna.org
Background Chimeric antigen receptor (CAR) T cells are a promising cancer therapy;
however, reliable and repeatable methods for tracking and monitoring CAR T cells in vivo …

H2CHXhox: Rigid Cyclohexane-Reinforced Nonmacrocyclic Chelating Ligand for [nat/67/68Ga]Ga3+

X Wang, MG Jaraquemada-Pelaez, Y Cao… - Inorganic …, 2020 - ACS Publications
A rigid chiral acyclic chelator H2 CHX hox was synthesized and evaluated for Ga3+-based
radiopharmaceutical applications; it was compared to the previously reported hexadentate …

68Ga-Labeled Maleimide for Blood Pool and Lymph PET Imaging through Covalent Bonding to Serum Albumin In Vivo

L Feng, J Fang, X Zeng, H Liu, J Zhang, L Huang… - ACS …, 2022 - ACS Publications
This study aims to develop a novel 68Ga-labeled tracer, which can covalently bind to
albumin in vivo based on the maleimide–thiol strategy, and to evaluate its potential …

Synthesis and ex vivo biodistribution of two 68Ga-labeled tetrazine tracers: comparison of pharmacokinetics

E Lambidis, D Lumén, E Koskipahta… - Nuclear Medicine and …, 2022 - Elsevier
Pretargeted PET imaging allows the use of radiotracers labeled with short-living PET
radionuclides for tracing drugs with slow pharmacokinetics. Recently, especially methods …

[HTML][HTML] Evaluation of [68Ga]Ga-DOTA-AeK as a Potential Imaging Tool for PET Imaging of Cell Wall Synthesis in Bacterial Infections

PC Koatale, MM Welling, S Mdanda, A Mdlophane… - Pharmaceuticals, 2024 - mdpi.com
The ability of bacteria to recycle exogenous amino acid-based peptides and amino sugars
for peptidoglycan biosynthesis was extensively investigated using optical imaging. In …

Bn2DT3A, a Chelator for 68Ga Positron Emission Tomography: Hydroxide Coordination Increases Biological Stability of [68Ga][Ga(Bn2DT3A)(OH)]

TW Price, I Renard, TJ Prior, V Kubicek… - Inorganic …, 2022 - ACS Publications
The chelator Bn2DT3A was used to produce a novel 68Ga complex for positron emission
tomography (PET). Unusually, this system is stabilized by a coordinated hydroxide in …