Is oxytocin “nature's medicine”?

CS Carter, WM Kenkel, EL MacLean, SR Wilson… - Pharmacological …, 2020 - ASPET
Oxytocin is a pleiotropic, peptide hormone with broad implications for general health,
adaptation, development, reproduction, and social behavior. Endogenous oxytocin and …

Brain oxytocin: how puzzle stones from animal studies translate into psychiatry

V Grinevich, ID Neumann - Molecular psychiatry, 2021 - nature.com
The neuropeptide oxytocin has attracted great attention of the general public, basic
neuroscience researchers, psychologists, and psychiatrists due to its profound pro-social …

An allostatic theory of oxytocin

DS Quintana, AJ Guastella - Trends in cognitive sciences, 2020 - cell.com
Oxytocin has garnered considerable interest for its role in social behavior, as well as for the
potential of intranasal administration to treat social difficulties. However, current theoretical …

[HTML][HTML] The oxytocin–vasopressin pathway in the context of love and fear

CS Carter - Frontiers in endocrinology, 2017 - frontiersin.org
Vasopressin (VP) and oxytocin (OT) are distinct molecules; these peptides and their
receptors [OT receptor (OTR) and V1a receptor (V1aR)] also are evolved components of an …

An analgesic pathway from parvocellular oxytocin neurons to the periaqueductal gray in rats

M Iwasaki, A Lefevre, F Althammer… - Nature …, 2023 - nature.com
The hypothalamic neuropeptide oxytocin (OT) exerts prominent analgesic effects via central
and peripheral action. However, the precise analgesic pathways recruited by OT are largely …

Infrequent intranasal oxytocin followed by positive social interaction improves symptoms in autistic children: a pilot randomized clinical trial

J Le, L Zhang, W Zhao, S Zhu, C Lan, J Kou… - Psychotherapy and …, 2022 - karger.com
Introduction: There are currently no approved drug interventions for social behavior
dysfunction in autism spectrum disorder (ASD). Previous trials investigating effects of daily …

Emerging role of astrocytes in oxytocin-mediated control of neural circuits and brain functions

A Baudon, EC Creusot, F Althammer, CP Schaaf… - Progress in …, 2022 - Elsevier
The neuropeptide oxytocin has been in the focus of scientists for decades due to its
profound and pleiotropic effects on physiology, activity of neuronal circuits and behaviors …

Oxytocin in women's health and disease

N Liu, H Yang, L Han, M Ma - Frontiers in endocrinology, 2022 - frontiersin.org
Oxytocin (OT) is a nonapeptide mainly produced in the supraoptic and paraventricular
nuclei. OT in the brain and blood has extensive functions in both mental and physical …

Effects of route of administration on oxytocin-induced changes in regional cerebral blood flow in humans

DA Martins, N Mazibuko, F Zelaya… - Nature …, 2020 - nature.com
Could nose-to-brain pathways mediate the effects of peptides such as oxytocin (OT) on brain
physiology when delivered intranasally? We address this question by contrasting two …

Social approach and social vigilance are differentially regulated by oxytocin receptors in the nucleus accumbens

AV Williams, N Duque-Wilckens… - …, 2020 - nature.com
Oxytocin is currently being considered as a novel therapeutic for anxiety disorders due to its
ability to promote affiliative behaviors. In the nucleus accumbens (NAc) activation of oxytocin …