Physiology of sedentary behavior

AJ Pinto, A Bergouignan, PC Dempsey… - Physiological …, 2023 - journals.physiology.org
Sedentary behaviors (SB) are characterized by low energy expenditure while in a sitting or
reclining posture. Evidence relevant to understanding the physiology of SB can be derived …

Multisystem physiological perspective of human frailty and its modulation by physical activity

JA Taylor, PL Greenhaff, DB Bartlett… - Physiological …, 2023 - journals.physiology.org
“Frailty” is a term used to refer to a state characterized by enhanced vulnerability to, and
impaired recovery from, stressors compared with a nonfrail state, which is increasingly …

[HTML][HTML] Lipid droplets in neurodegenerative disorders

BC Farmer, AE Walsh, JC Kluemper… - Frontiers in …, 2020 - frontiersin.org
Knowledge of lipid droplets (LDs) has evolved from simple depots of lipid storage to
dynamic and functionally active organelles involved in a variety of cellular functions. Studies …

[HTML][HTML] Sarcopenic obesity, insulin resistance, and their implications in cardiovascular and metabolic consequences

S Hong, KM Choi - International journal of molecular sciences, 2020 - mdpi.com
The prevalence of sarcopenic obesity is increasing worldwide, particularly amongst aging
populations. Insulin resistance is the core mechanism of sarcopenic obesity and is also …

[HTML][HTML] Sarcopenic obesity: an emerging public health problem

T Ji, Y Li, L Ma - Aging and disease, 2022 - ncbi.nlm.nih.gov
Population aging and the obesity epidemic are important global public health problems that
pose an unprecedented threat to the physical and mental health of the elderly and health …

Impact of different ectopic fat depots on cardiovascular and metabolic diseases

D Ferrara, F Montecucco, F Dallegri… - Journal of cellular …, 2019 - Wiley Online Library
A growing body of evidence is pointing out the pathophysiological role of fat accumulation in
different organs. Ectopic fat depots within heart, liver, skeletal muscle, kidney, and pancreas …

[HTML][HTML] Age-related changes in muscle architecture and metabolism in humans: the likely contribution of physical inactivity to age-related functional decline

NF Shur, L Creedon, S Skirrow, PJ Atherton… - Ageing Research …, 2021 - Elsevier
Abstract In the United Kingdom (UK), it is projected that by 2035 people aged> 65 years will
make up 23% of the population, with those aged> 85 years accounting for 5% of the total …

[HTML][HTML] Are fruit juices healthier than sugar-sweetened beverages? A review

A Pepin, KL Stanhope, P Imbeault - Nutrients, 2019 - mdpi.com
Free sugars overconsumption is associated with an increased prevalence of risk factors for
metabolic diseases such as the alteration of the blood lipid levels. Natural fruit juices have a …

[HTML][HTML] Effects of SGLT2 inhibitor dapagliflozin in patients with type 2 diabetes on skeletal muscle cellular metabolism

YJM op den Kamp, A Gemmink, M de Ligt… - Molecular …, 2022 - Elsevier
Objective SGLT2 inhibitors increase urinary glucose excretion and have beneficial effects on
cardiovascular and renal outcomes; the underlying mechanism may be metabolic …

[HTML][HTML] An aPPARent functional consequence in skeletal muscle physiology via peroxisome proliferator-activated receptors

WWT Phua, MXY Wong, Z Liao, NS Tan - International journal of …, 2018 - mdpi.com
Skeletal muscle comprises 30–40% of the total body mass and plays a central role in energy
homeostasis in the body. The deregulation of energy homeostasis is a common underlying …