Targeted therapy for head and neck cancer: signaling pathways and clinical studies

Q Li, Y Tie, A Alu, X Ma, H Shi - Signal transduction and targeted …, 2023 - nature.com
Head and neck cancer (HNC) is malignant, genetically complex and difficult to treat and is
the sixth most frequent cancer, with tobacco, alcohol and human papillomavirus being major …

Advances in molecular targeted therapies to increase efficacy of (chemo) radiation therapy

K Viktorsson, T Rieckmann, M Fleischmann… - Strahlentherapie und …, 2023 - Springer
Recent advances in understanding the tumor's biology in line with a constantly growing
number of innovative technologies have prompted characterization of patients' individual …

A comprehensive review on role of Aurora kinase inhibitors (AKIs) in cancer therapeutics

D Gupta, M Kumar, S Saifi, S Rawat… - International Journal of …, 2024 - Elsevier
Aurora kinases (AURKs) are a family of serine/threonine protein kinases that have a crucial
role in cell cycle process mainly in the event of chromosomal segregation, centrosome …

Social, ethical and treatment related problems faced by healthcare workers in the care of head and neck cancer patients: A narrative review from the bioethics …

MS Baliga, S Lasrado, A Krishna, T George… - Indian Journal of …, 2023 - Springer
Head and neck cancer (HNC) presents a variety of ethical difficulties for an oncologist
involved in screening, diagnosis, treatment, and rehabilitation that are challenging to …

[HTML][HTML] Impaired DNA double-strand break repair and effective radiosensitization of HPV-negative HNSCC cell lines through combined inhibition of PARP and Wee1

A Oetting, S Christiansen, F Gatzemeier… - Clinical and …, 2023 - Elsevier
Objectives In head and neck squamous cell carcinoma (HNSCC), tumors negative for
Human Papillomavirus (HPV) remain a difficult to treat entity and the morbidity of current …

Comprehensive Insights into Oral Squamous Cell Carcinoma: Diagnosis, Pathogenesis, and Therapeutic Advances

D Jagadeesan, KV Sathasivam, NK Fuloria… - … -Research and Practice, 2024 - Elsevier
Oral squamous cell carcinoma (OSCC) is considered the most common type of head and
neck squamous cell carcinoma (HNSCC) as it holds 90% of HNSCC cases that arise from …

Efficacy of depatuxizumab mafodotin (ABT-414) in preclinical models of head and neck cancer

L Mani, A Naveed, A McAdoo, E Rosenthal… - …, 2024 - academic.oup.com
Epidermal growth factor receptor (EGFR) is highly expressed in 80–90% of head and neck
squamous cell carcinomas (HNSCCs), making it an ideal target for antibody–drug …

Targeting BRD4: Potential therapeutic strategy for head and neck squamous cell carcinoma

V Yongprayoon, N Wattanakul… - Oncology …, 2024 - spandidos-publications.com
As a member of BET (bromodomain and extra-terminal) protein family, BRD4 (bromodomain‑
containing protein 4) is a chromatin‑associated protein that interacts with acetylated histones …

An epidermal growth factor receptor‐targeting immunotoxin based on IgG shows potent antitumor activity against head and neck cancer

M Huang, J Park, J Seo, S Ko, YH Yang… - The FASEB …, 2024 - Wiley Online Library
The epidermal growth factor receptor (EGFR) is an important target for cancer therapies.
Many head and neck cancer (HNC) cells have been reported to overexpress EGFR; …

Radiation-induced skin injury in the head and neck region: pathogenesis, clinics, prevention, treatment considerations and proposal for management algorithm

J Pazdrowski, J Gornowicz-Porowska… - Reports of Practical …, 2024 - journals.viamedica.pl
Worldwide increase o fh ead and neck cancers ranks thes em alignancies among top
causes of cancer i nh uman population. Radiation induced skin injury (RISI) is one of th em …