The kynurenine pathway (KP) is highly regulated in the immune system, where it promotes
immunosuppression in response to infection or inflammation. Indoleamine 2, 3-dioxygenase …

The physiological markers of autoimmune diabetes include functional disorders of the
antioxidative system as well as progressing inflammation and the presence of …

Although multiple pancreatic islet single-cell RNA-sequencing (scRNA-seq) datasets have
been generated, a consensus on pancreatic cell states in development, homeostasis and …

Type 1 diabetes (T1D) is an autoimmune disease characterized by the T-cell-mediated
destruction of insulin-producing β-cells in pancreatic islets. It generally occurs in genetically …

A variety of islet autoantibodies (AAbs) can predict and possibly dictate eventual type 1
diabetes (T1D) diagnosis. Upwards of 75% of those with T1D are positive for AAbs against …

Target delivery of therapeutic agents with anti-inflammatory properties using probiotics as
delivery and recombinant protein expression vehicles is a promising approach for the …

Peptide loading of MHC class II (MHCII) molecules is facilitated by HLA-DM (DM), which
catalyzes CLIP release, stabilizes empty MHCII, and edits the MHCII-bound peptide …

Type 1 diabetes results from the poorly understood process of islet autoimmunity, which
ultimately leads to the loss of functional pancreatic beta cells. Mounting evidence supports …

Abstract Type 1 diabetes (T1D) is a chronic, progressive autoinflammatory disorder resulting
from the breakdown of self-tolerance and unrestrained β cell-reactive immune response …

T-cell-mediated autoimmune type 1 diabetes (T1D) is characterized by the immune-
mediated destruction of pancreatic beta cells (β-cells). The increasing prevalence of T1D …