Protein S‐palmitoylation (hereinafter referred to as protein palmitoylation) is a reversible
lipid posttranslational modification catalyzed by the zinc finger DHHC‐type containing …

Simple Summary Several studies showed that oxidative stress is involved in cancer
occurrence, development, progression chemoresistance and radio resistance. The nuclear …

Proteolysis targeting chimera (PROTAC) is an emerging pharmacological modality with
innovated post‐translational protein degradation capabilities. However, off‐target induced …

DEAD-box (DDX) 5 and DDX17, which belong to the DEAD-box RNA helicase family, are
nuclear and cytoplasmic shuttle proteins. These proteins are expressed in most tissues and …

Prostate cancer (PCa) is a leading cause of cancer death in men, worldwide. Mortality is
highly related to metastasis and hormone resistance, but the molecular underlying …

The widespread application of antiandrogen therapies has aroused a significant increase in
the incidence of NEPC, a lethal form of the disease lacking efficient clinical treatments. Here …

The role of endocrine disruptors (EDs) in the human prostate gland is an overlooked issue
even though the prostate is essential for male fertility. From experimental models, it is known …

It is known that estrogen stimulates growth and inhibits apoptosis through estrogen receptor
(ER)-mediated mechanisms in many cancer cell types. Interestingly, there is strong evidence …

Simple Summary Prostate cancer is a malignancy that affects a high number of men all over
the world. When indolent, prostate cancer can remain silent for years without needing …

In order to proliferate in unfavourable conditions, cancer cells can take advantage of the
naturally occurring endoplasmic reticulum-associated unfolded protein response (UPR) via …