Seasonal modulation of the testis transcriptome reveals insights into hibernation and reproductive adaptation in Onychostoma macrolepis
Y Ma, Y Chen, Y Li, S Chen, C Zhu, Q Liu, L Li… - Fish Physiology and …, 2024 - Springer
The Onychostoma macrolepis have a unique survival strategy, overwintering in caves and
returning to the river for reproduction in summer. The current knowledge on the …
returning to the river for reproduction in summer. The current knowledge on the …
Evaluation of AR, AR-V7, and p160 family as biomarkers for prostate cancer: insights into the clinical significance and disease progression
Purpose To assess the role of the p160 family, AR, and AR-V7 in different initial
presentations of prostate cancer and their association with clinical endpoints related to …
presentations of prostate cancer and their association with clinical endpoints related to …
Development and validation of a tumor immune cell infiltration-related gene signature for recurrence prediction by weighted gene co-expression network analysis in …
LY Xie, HY Huang, YL Hao, M Yu, W Zhang… - Frontiers in …, 2023 - frontiersin.org
Introduction: Prostate cancer (PCa) is the second most common malignancy in men. Despite
multidisciplinary treatments, patients with PCa continue to experience poor prognoses and …
multidisciplinary treatments, patients with PCa continue to experience poor prognoses and …
Orally Bioavailable Proteolysis-Targeting Chimeras: An Innovative Approach in the Golden Era of Discovering Small-Molecule Cancer Drugs
Proteolysis-targeting chimeras (PROTACs) are an emerging therapeutic modality that show
promise to open a target space not accessible to conventional small molecules via a …
promise to open a target space not accessible to conventional small molecules via a …
Understanding human aging and the fundamental cell signaling link in age-related diseases: the middle-aging hypovascularity hypoxia hypothesis
TJ Phua - Frontiers in aging, 2023 - frontiersin.org
Aging-related hypoxia, oxidative stress, and inflammation pathophysiology are closely
associated with human age-related carcinogenesis and chronic diseases. However, the …
associated with human age-related carcinogenesis and chronic diseases. However, the …
[HTML][HTML] The androgen receptor inhibits transcription of GPER1 by preventing Sp1 and Sp3 from binding to the promoters in prostate cancer cells
Abstract G-1, a GPER1 agonist, was shown to inhibit the growth of castration-resistant
mouse xenografts but not their parental androgen-dependent tumors. It is currently unknown …
mouse xenografts but not their parental androgen-dependent tumors. It is currently unknown …
Computational prediction of 11β-hydroxysteroid dehydrogenase inhibitors from n-butanol fraction of Blighia welwetschii (Hiern) leaf for the management of type-2 …
TC Aribigbola, DA Omoboyowa… - Journal of Biomolecular …, 2023 - Taylor & Francis
Human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) is an enzyme that catalyzes
the generation of active cortisol from cortisone, thus regulating the availability of …
the generation of active cortisol from cortisone, thus regulating the availability of …
Roles of key epigenetic regulators in the gene transcription and progression of prostate cancer
T Deng, Y Xiao, Y Dai, L Xie, X Li - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
Prostate cancer (PCa) is a top-incidence malignancy, and the second most common cause
of death amongst American men and the fifth leading cause of cancer death in men around …
of death amongst American men and the fifth leading cause of cancer death in men around …
Targeting the autophagy-miRNA axis in prostate cancer: toward novel diagnostic and therapeutic strategies
Since prostate cancer is one of the leading causes of cancer-related death, a better
understanding of the molecular pathways guiding its development is imperative. A key factor …
understanding of the molecular pathways guiding its development is imperative. A key factor …
[HTML][HTML] Mucinous metaplasia in Pten conditional knockout mice and mucin family genes as prognostic markers for prostate cancer
NJ Santos, PP Ximenes, FB Constantino, HF Carvalho… - Life sciences, 2022 - Elsevier
Aims This study evaluated the association of mucinous metaplasia (MM) with tumor cell
proliferation, androgen receptor (AR) expression and invasiveness in Pten conditional …
proliferation, androgen receptor (AR) expression and invasiveness in Pten conditional …