[HTML][HTML] SARS-CoV-2 Omicron variant: recent progress and future perspectives

Y Fan, X Li, L Zhang, S Wan, L Zhang… - Signal transduction and …, 2022 - nature.com
Since the outbreak of the coronavirus disease 2019 (COVID-19) pandemic, there have been
a few variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), one of …

Evolution of the SARS‐CoV‐2 omicron variants BA. 1 to BA. 5: implications for immune escape and transmission

LB Shrestha, C Foster, W Rawlinson… - Reviews in Medical …, 2022 - Wiley Online Library
The first dominant SARS‐CoV‐2 Omicron variant BA. 1 harbours 35 mutations in its Spike
protein from the original SARS‐CoV‐2 variant that emerged late 2019. Soon after its …

Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution

Y Cao, F Jian, J Wang, Y Yu, W Song, A Yisimayi… - Nature, 2023 - nature.com
Continuous evolution of Omicron has led to a rapid and simultaneous emergence of
numerous variants that display growth advantages over BA. 5 (ref.). Despite their divergent …

[HTML][HTML] BA. 2.12. 1, BA. 4 and BA. 5 escape antibodies elicited by Omicron infection

Y Cao, A Yisimayi, F Jian, W Song, T Xiao, L Wang… - Nature, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sublineages BA.
2.12. 1, BA. 4 and BA. 5 exhibit higher transmissibility than the BA. 2 lineage 1. The receptor …

The immunology and immunopathology of COVID-19

M Merad, CA Blish, F Sallusto, A Iwasaki - Science, 2022 - science.org
Considerable research effort has been made worldwide to decipher the immune response
triggered upon severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections …

[HTML][HTML] Modeling transmission of SARS-CoV-2 omicron in China

J Cai, X Deng, J Yang, K Sun, H Liu, Z Chen, C Peng… - Nature medicine, 2022 - nature.com
Having adopted a dynamic zero-COVID strategy to respond to SARS-CoV-2 variants with
higher transmissibility since August 2021, China is now considering whether, and for how …

Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity

B Meng, A Abdullahi, IATM Ferreira, N Goonawardane… - Nature, 2022 - nature.com
Abstract The SARS-CoV-2 Omicron BA. 1 variant emerged in 2021 and has multiple
mutations in its spike protein. Here we show that the spike protein of Omicron has a higher …

SARS-CoV-2 Omicron variant replication in human bronchus and lung ex vivo

KPY Hui, JCW Ho, M Cheung, K Ng, RHH Ching, K Lai… - Nature, 2022 - nature.com
The emergence of SARS-CoV-2 variants of concern with progressively increased
transmissibility between humans is a threat to global public health. The Omicron variant of …

T cell responses to SARS-CoV-2 spike cross-recognize Omicron

R Keeton, MB Tincho, A Ngomti, R Baguma, N Benede… - Nature, 2022 - nature.com
Abstract The SARS-CoV-2 Omicron variant (B. 1.1. 529) has multiple spike protein
mutations, that contribute to viral escape from antibody neutralization,,–and reduce vaccine …

Attenuated fusogenicity and pathogenicity of SARS-CoV-2 Omicron variant

R Suzuki, D Yamasoba, I Kimura, L Wang, M Kishimoto… - Nature, 2022 - nature.com
The emergence of the Omicron variant of SARS-CoV-2 is an urgent global health concern. In
this study, our statistical modelling suggests that Omicron has spread more rapidly than the …