Radiotherapy (RT) is a highly effective anticancer treatment that is delivered to more than
half of all patients with cancer. In addition to the well-documented direct cytotoxic effects, RT …

Age-related diseases, including age-related macular degeneration (AMD), are of growing
importance in a world where population ageing has become a dominant global trend …

Currently, we lack an understanding of the individual and combinatorial roles for chemokine
receptors in the inflammatory process. We report studies on mice with a compound deletion …

Neutrophils are the most abundant leukocytes in human blood and critical actors of the
immune system. Many neutrophil functions and facets of their activity in vivo were revealed …

Background COVID-19 is associated with a dysregulated immune response but it is unclear
how immune dysfunction contributes to the chronic morbidity persisting in many COVID-19 …

In the presence of tissue inflammation, injury, or cancer, myeloid cells are recruited to
disease regions through a multi-step process involving myelopoiesis, chemotaxis, cell …

Pancreatic ductal adenocarcinoma (PDAC) is characterized by dense stromal reaction
(desmoplasia). We have previously reported that mice with conditional Kras G12D mutation …

Simple Summary While the development of immunotherapy has greatly advanced cancer
treatment, many patients do not benefit from immunotherapy. Numerous strategies have …

Chemokines (chemotactic cytokines) and their receptors are critical to recruitment and
positioning of cells during development and the immune response. The chemokine system …

The bioavailability and regulation of iron is essential for central biological functions in
mammals. The role of this element in ferroptosis and the dysregulation of its metabolism …