ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …

Multiple sclerosis (MS) and neuromyelitis optica (NMO) are autoimmune demyelinating
diseases of the central nervous system (CNS), having distinct immunological and …

Changes in gene expression that occur across the central nervous system (CNS) during
neurological diseases do not address the heterogeneity of cell types from one CNS region to …

Over the last decade knowledge of the role of astrocytes in central nervous system (CNS)
neuroinflammatory diseases has changed dramatically. Rather than playing a merely …

In the central nervous system, oligodendrocytes produce myelin sheaths that enwrap
neuronal axons to provide trophic support and increase conduction velocity. New …

Astrocytes are essential for the development and homeostatic maintenance of the central
nervous system (CNS). They are also critical players in the CNS injury response during …

The blood–brain barrier (BBB) helps maintain a tightly regulated microenvironment for
optimal central nervous system (CNS) homeostasis and facilitates communications with the …

Glial subtype diversity is an emerging topic in neurobiology and immune-mediated
neurological diseases such as multiple sclerosis (MS). We discuss recent conceptual and …

Microglia, brain cells of nonneural origin, orchestrate the inflammatory response to diverse
insults, including hypoxia/ischemia or maternal/fetal infection in the perinatal brain …

Multiple Sclerosis (MS) is the most common cause of acquired neurological disability in
young adults, pathologically characterized by leukocyte infiltration of the central nervous …