Lysosomes serve as catabolic centers and signaling hubs in cells, regulating a multitude of
cellular processes such as intracellular environment homeostasis, macromolecule …

Despite ongoing advancements in cancer treatment, the emergence of primary and acquired
resistance poses a significant challenge for both traditional chemotherapy and immune …

Nutrient signaling: Starvation flips a phosphoinositide switch on lysosomal catabolism:
Current Biology Skip to Main Content Advertisement Current Biology This journal offers …

In sarcoidosis, granulomas develop in multiple organs including the liver and lungs.
Although mechanistic target of rapamycin complex 1 (mTORC1) activation in macrophages …

Developing drug-free nanotherapeutics is extremely appealing provided they could achieve
effective therapeutic performances. This study proposes a sodium bicarbonate-dependent …

The artificial manipulation of exogenous molecules in living cells is a promising means to
regulate cellular behaviors. However, the spatiotemporal control of self-assembly within the …

Aberrant metabolism and nutrient processing are hallmarks in cancer. Autophagy is a
catabolic process, clearing macromolecules and providing metabolite intermediates for …

Experimental studies in flies, mice, and humans suggest a significant role of impaired axonal
transport in the pathogenesis of Alzheimer's disease (AD). The mechanisms underlying …

Swainsonine (SW) is the main toxic component of locoweed. Previous studies have shown
that kidney damage is an early pathologic change in locoweed poisoning in animals …

The nuclear envelope (NE) is a critical component in maintaining the function and structure
of the eukaryotic nucleus. The NE and lamina are disassembled during each cell cycle to …