[HTML][HTML] A review of inflammatory mechanism in airway diseases

P Aghasafari, U George, R Pidaparti - Inflammation Research, 2019 - Springer
Background Inflammation in the lung is the body's natural response to injury. It acts to
remove harmful stimuli such as pathogens, irritants, and damaged cells and initiate the …

Eosinophilic airway inflammation: role in asthma and chronic obstructive pulmonary disease

L George, CE Brightling - Therapeutic advances in chronic …, 2016 - journals.sagepub.com
The chronic lung diseases, asthma and chronic obstructive pulmonary disease (COPD), are
common affecting over 500 million people worldwide and causing substantial morbidity and …

[HTML][HTML] Can indoor sports centers be allowed to re-open during the COVID-19 pandemic based on a certificate of equivalence?

B Blocken, T Van Druenen, T Van Hooff… - Building and …, 2020 - Elsevier
Within a time span of only a few months, the SARS-CoV-2 virus has managed to spread
across the world. This virus can spread by close contact, which includes large droplet spray …

Poor translatability of biomedical research using animals—A narrative review

LJ Marshall, J Bailey, M Cassotta… - Alternatives to …, 2023 - journals.sagepub.com
The failure rate for the translation of drugs from animal testing to human treatments remains
at over 92%, where it has been for the past few decades. The majority of these failures are …

Personalized medicine for patients with COPD: where are we?

FME Franssen, P Alter, N Bar… - … journal of chronic …, 2019 - Taylor & Francis
Chronic airflow limitation is the common denominator of patients with chronic obstructive
pulmonary disease (COPD). However, it is not possible to predict morbidity and mortality of …

[HTML][HTML] Why we should target small airways disease in our management of chronic obstructive pulmonary disease

OS Usmani, R Dhand, F Lavorini, D Price - Mayo Clinic Proceedings, 2021 - Elsevier
For more than 50 years, small airways disease has been considered a key feature of chronic
obstructive pulmonary disease (COPD) and a major cause of airway obstruction. Both …

[HTML][HTML] Persistent mucus plugs in proximal airways are consequential for airflow limitation in asthma

BK Huang, BM Elicker, TS Henry, KG Kallianos… - JCI insight, 2024 - ncbi.nlm.nih.gov
BACKGROUND Information about the size, airway location, and longitudinal behavior of
mucus plugs in asthma is needed to understand their role in mechanisms of airflow …

The virtual physiological human: ten years after

M Viceconti, P Hunter - Annual review of biomedical …, 2016 - annualreviews.org
Biomedical research and clinical practice are struggling to cope with the growing complexity
that the progress of health care involves. The most challenging diseases, those with the …

[HTML][HTML] Structural and functional alterations of the tracheobronchial tree after left upper pulmonary lobectomy for lung cancer

Q Gu, S Qi, Y Yue, J Shen, B Zhang, W Sun… - Biomedical engineering …, 2019 - Springer
Background Pulmonary lobectomy has been a well-established curative treatment method
for localized lung cancer. After left upper pulmonary lobectomy, the upward displacement of …

[HTML][HTML] Micrometer-resolution X-ray tomographic full-volume reconstruction of an intact post-mortem juvenile rat lung

E Borisova, G Lovric, A Miettinen, L Fardin… - Histochemistry and cell …, 2021 - Springer
In this article, we present an X-ray tomographic imaging method that is well suited for
pulmonary disease studies in animal models to resolve the full pathway from gas intake to …