Neuropathic pain caused by a lesion or disease of the somatosensory nervous system is a
common chronic pain condition with major impact on quality of life. Examples include …

Chronic pain is a maladaptive neurological disease that remains a major health problem. A
deepening of our knowledge on mechanisms that cause pain is a prerequisite to developing …

Distinct types of dorsal root ganglion sensory neurons may have unique contributions to
chronic pain. Identification of primate sensory neuron types is critical for understanding the …

Peripheral nerve injury could lead to chronic neuropathic pain. Understanding
transcriptional changes induced by nerve injury could provide fundamental insights into the …

In humans, tissue injury and depression can both cause pain hypersensitivity, but whether
this involves distinct circuits remains unknown. Here, we identify two discrete glutamatergic …

Abstract Background and Purpose In these guidelines, we aimed to develop evidence‐
based recommendations for the use of screening questionnaires and diagnostic tests in …

Abstract Treatment of neuropathic pain remains inadequate despite the elucidation of
multiple pathophysiological mechanisms and the development of promising therapeutic …

The persistence of increased excitability and spontaneous activity in injured peripheral
neurons is imperative for the development and persistence of many forms of neuropathic …

Neuropathic pain arises as a direct consequence of a lesion or disease affecting the
somatosensory system. 87 It can be peripheral in origin, as a result of nerve injury or …

Current treatments for chronic pain rely largely on opioids despite their substantial side
effects and risk of addiction. Genetic studies have identified in humans key targets pivotal to …