Cardiovascular diseases (CVDs) are the primary drivers of the growing public health
epidemic and the leading cause of premature mortality and economic burden worldwide …

Aortic aneurysm and dissection (AAD) are a group of insidious and lethal cardiovascular
diseases that characterized by seriously threatening the life and health of people, but lack …

Orthopedic implants have a high failure rate due to insufficient interfacial osseointegration,
especially under osteoporotic conditions. Type H vessels are CD31+ EMCN+ capillaries …

Background Alveolar macrophages are one of the momentous regulators in pulmonary
inflammatory responses, which can secrete extracellular vesicles (EVs) packing miRNAs …

Peritoneal metastasis (PM) has a suppressive tumor immune microenvironment (TIME) that
limits the effects of immunotherapy. This study aimed to investigate the immunomodulatory …

Background Paclitaxel (PTX) treatment resistance is an important factor leading to poor
prognosis in triple-negative breast cancer (TNBC), therefore there is an urgent need to …

Colistin is used as the “last line of defense” against multidrug-resistant (MDR) Gram-
negative bacteria (GNB). However, improper use of colistin may further lead to an increasing …

Abstract Background Abdominal aortic aneurysms (AAAs) can result in high mortality upon
rupture but are usually undiagnosed because of the absence of symptoms in the early stage …

Large-scale screening of molecules in organisms requires high-throughput and cost-
effective evaluating tools during preclinical development. Here, a novel in vivo screening …

Abstract Interferon regulatory factor 4 (IRF4) is expressed in immune cells and is a member
of the interferon regulatory factor family. Recently, it has been found that IRF4 plays …