The age-related dysregulation and decline of the immune system—collectively termed
“immunosenescence”—has been generally associated with an increased susceptibility to …

Aging results in remodeling of T cell immunity and is associated with poor clinical outcomes
in age-related diseases such as cancer. Among the hallmarks of aging, changes in host and …

Signals from commensal bacteria can influence immune cell development and susceptibility
to infectious or inflammatory diseases. However, the mechanisms by which commensal …

Innate lymphoid cells (ILCs), a heterogeneous cell population, are critical in orchestrating
immunity and inflammation in the intestine, but whether ILCs influence immune responses or …

Lung-resident memory CD8 T cells (TRM) induced by influenza A virus (IAV) that are pivotal
for providing subtype-transcending protection against IAV infection (heterosubtypic …

Age-associated decreases in primary CD8+ T cell responses occur, in part, due to direct
effects on naive CD8+ T cells to reduce intrinsic functionality, but the precise nature of this …

Lower respiratory viral infections, such as influenza virus and severe acute respiratory
syndrome coronavirus 2 infections, often cause severe viral pneumonia in aged individuals …

Seasonal epidemics of influenza virus result in∼ 36,000 deaths annually in the United
States. Current vaccines against influenza virus elicit an antibody response specific for the …

Influenza (flu) is a serious disease for older adults, with increased severity of infection and
greater risk for hospitalization and death. Flu infection is limited to pulmonary epithelial cells …

Immunosenescence is a process associated with aging that leads to dysregulation of cells of
innate and adaptive immunity, which may become dysfunctional. Consequently, older adults …